In 1980, the Uniformed Services University of the Health Sciences (USU) graduated its first class of medical students. As a national university intended to produce “career-committed” military officers and future leaders of the Military Health System, USU functions as the service academy for military medicine and public health. More than 40 years after the school’s charter and 5,000 graduates since the first class, we describe the original purpose of USU and provide an update on its achievements. In particular, we address the question of the “staying power” of the University’s alumni—the degree to which graduation from the nation’s military medical school is associated with long years of devoted service to military medicine. At a time when the MHS is confronting the challenge of extended deployments, rising health care costs, and a growing array of threats to our nation’s health, we suggest that America needs USU now more than ever.