@inproceedings{9f983bf373c54368911fec0796541360,
title = "Amyloid-β dynamics correlate with neurological status in the injured human brain",
abstract = "The amyloid-β peptide (Aβ) plays a central pathophysiological role in Alzheimer's disease, but virtually nothing is known about the concentration and dynamics of this secreted peptide in the extracellular space of the human brain. We used intracerebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were undergoing invasive intracranial monitoring after acute brain injury. We found a strong positive correlation between changes in brain ISF Aβ levels and neurological status, and correlations with other cerebral physiological and metabolic abnormalities reflecting depressed neuronal function. Such dynamics fit well with the hypothesis that neuronal activity regulates extracellular Aβ concentration.",
keywords = "Alzheimer disease, Amyloid beta, Microdialysis, Subarachnoid hemorrhage, Traumatic brain injury",
author = "Brody, {David L.} and Sandra Magnoni and Schwetye, {Kate E.} and Michael Spinner and Esparza, {Thomas J.} and Nino Stocchetti and Zipfel, {Greg J.} and Holtzman, {David M.}",
year = "2009",
doi = "10.1109/ICBBE.2009.5162305",
language = "English",
isbn = "9781424429028",
series = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",
booktitle = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",
note = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 ; Conference date: 11-06-2009 Through 13-06-2009",
}