An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

Brian M. Sicari; J. Peter Rubin; Christopher L. Dearth; Matthew T. Wolf; Fabrisia Ambrosio; Michael Boninger; Neill J. Turner; Douglas J. Weber; Tyler W. Simpson; Aaron Wyse; Elke H.P. Brown; Jenna L. Dziki; Lee E. Fisher; Spencer Brown; Stephen F. Badylak

doi:10.1126/scitranslmed.3008085

An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

Brian M. Sicari, J. Peter Rubin, Christopher L. Dearth, Matthew T. Wolf, Fabrisia Ambrosio, Michael Boninger, Neill J. Turner, Douglas J. Weber, Tyler W. Simpson, Aaron Wyse, Elke H.P. Brown, Jenna L. Dziki, Lee E. Fisher, Spencer Brown, Stephen F. Badylak^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

376 Scopus citations

Abstract

Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.

Original language	English
Article number	234ra58
Journal	Science Translational Medicine
Volume	6
Issue number	234
DOIs	https://doi.org/10.1126/scitranslmed.3008085
State	Published - 30 Apr 2014
Externally published	Yes

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Sicari, B. M., Peter Rubin, J., Dearth, C. L., Wolf, M. T., Ambrosio, F., Boninger, M., Turner, N. J., Weber, D. J., Simpson, T. W., Wyse, A., Brown, E. H. P., Dziki, J. L., Fisher, L. E., Brown, S., & Badylak, S. F. (2014). An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss. Science Translational Medicine, 6(234), Article 234ra58. https://doi.org/10.1126/scitranslmed.3008085

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title = "An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss",

abstract = "Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.",

author = "Sicari, {Brian M.} and {Peter Rubin}, J. and Dearth, {Christopher L.} and Wolf, {Matthew T.} and Fabrisia Ambrosio and Michael Boninger and Turner, {Neill J.} and Weber, {Douglas J.} and Simpson, {Tyler W.} and Aaron Wyse and Brown, {Elke H.P.} and Dziki, {Jenna L.} and Fisher, {Lee E.} and Spencer Brown and Badylak, {Stephen F.}",

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doi = "10.1126/scitranslmed.3008085",

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Sicari, BM, Peter Rubin, J, Dearth, CL, Wolf, MT, Ambrosio, F, Boninger, M, Turner, NJ, Weber, DJ, Simpson, TW, Wyse, A, Brown, EHP, Dziki, JL, Fisher, LE, Brown, S & Badylak, SF 2014, 'An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss', Science Translational Medicine, vol. 6, no. 234, 234ra58. https://doi.org/10.1126/scitranslmed.3008085

TY - JOUR

T1 - An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

AU - Sicari, Brian M.

AU - Peter Rubin, J.

AU - Dearth, Christopher L.

AU - Wolf, Matthew T.

AU - Ambrosio, Fabrisia

AU - Boninger, Michael

AU - Turner, Neill J.

AU - Weber, Douglas J.

AU - Simpson, Tyler W.

AU - Wyse, Aaron

AU - Brown, Elke H.P.

AU - Dziki, Jenna L.

AU - Fisher, Lee E.

AU - Brown, Spencer

AU - Badylak, Stephen F.

PY - 2014/4/30

Y1 - 2014/4/30

N2 - Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.

AB - Biologic scaffolds composed of naturally occurring extracellular matrix (ECM) can provide a microenvironmental niche that alters the default healing response toward a constructive and functional outcome. The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. Porcine urinary bladder ECM scaffold implantation was associated with perivascular stem cell mobilization and accumulation within the site of injury, and de novo formation of skeletal muscle cells. The ECM-mediated constructive remodeling was associated with stimulus-responsive skeletal muscle in rodents and functional improvement in three of the five human patients.

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U2 - 10.1126/scitranslmed.3008085

DO - 10.1126/scitranslmed.3008085

M3 - Article

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AN - SCOPUS:84899856041

SN - 1946-6234

VL - 6

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 234

M1 - 234ra58

ER -

An acellular biologic scaffold promotes skeletal muscle formation in mice and humans with volumetric muscle loss

Abstract

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