An assay to quantify chemotactic properties of degradation products from extracellular matrix

Brian M. Sicari, Li Zhang, Ricardo Londono, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations

Abstract

The endogenous chemotaxis of cells toward sites of tissue injury and/or biomaterial implantation is an important component of the host response. Implanted biomaterials capable of recruiting host stem/progenitor cells to a site of interest may obviate challenges associated with cell transplantation. An assay for the identification and quantification of chemotaxis induced by surgically placed biologic scaffolds composed of extracellular matrix is described herein.

Original languageEnglish
Title of host publicationBiomimetics and Stem Cells
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages103-110
Number of pages8
ISBN (Print)9781493913312
DOIs
StatePublished - 2014
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1202
ISSN (Print)1064-3745

Keywords

  • Chemotaxis
  • Cryptic peptides
  • Extracellular matrix
  • Stem cells

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