An in vivo model system for evaluation of the host response to biomaterials

Brian Sicari, Neill Turner, Stephen F. Badylak

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

16 Scopus citations


We describe an in vivo model system designed to evaluate the host response to implanted biomaterials: The partial thickness rat abdominal wall defect model. The model allows for determination of the temporal and spatial distribution of the cellular and vascular response, the remodeling of the implanted material and surrounding host soft tissue, and the function of the remodeled tissue over time.

Original languageEnglish
Title of host publicationWound Regeneration and Repair
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Number of pages23
ISBN (Print)9781627035040
StatePublished - 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Abdominal wall defect
  • Biomaterials
  • Soft tissue reconstruction


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