An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement

Cynthia Ménard; Robert C. Susil; Peter Choyke; Jonathan Coleman; Robert Grubb; Ahmed Gharib; Axel Krieger; Peter Guion; David Thomasson; Karen Ullman; Sandeep Gupta; Virginia Espina; Lance Liotta; Emanuel Petricoin; Gabor Fitchtinger; Louis L. Whitcomb; Ergin Atalar; C. Norman Coleman; Kevin Camphausen

An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement

Cynthia Ménard, Robert C. Susil^*, Peter Choyke, Jonathan Coleman, Robert Grubb, Ahmed Gharib, Axel Krieger, Peter Guion, David Thomasson, Karen Ullman, Sandeep Gupta, Virginia Espina, Lance Liotta, Emanuel Petricoin, Gabor Fitchtinger, Louis L. Whitcomb, Ergin Atalar, C. Norman Coleman, Kevin Camphausen

^*Corresponding author for this work

Surgery

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The biological characterization of an individual patient's tumor by noninvasive Imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.

Original language	English
Pages (from-to)	63-66
Number of pages	4
Journal	Molecular Imaging
Volume	4
Issue number	1
State	Published - 2005

Keywords

Angiogenesis
Interventional MRI
Micro-array analysis
Molecular imaging
Prostate cancer

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Ménard, C., Susil, R. C., Choyke, P., Coleman, J., Grubb, R., Gharib, A., Krieger, A., Guion, P., Thomasson, D., Ullman, K., Gupta, S., Espina, V., Liotta, L., Petricoin, E., Fitchtinger, G., Whitcomb, L. L., Atalar, E., Norman Coleman, C., & Camphausen, K. (2005). An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement. Molecular Imaging, 4(1), 63-66.

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title = "An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement",

abstract = "The biological characterization of an individual patient's tumor by noninvasive Imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.",

keywords = "Angiogenesis, Interventional MRI, Micro-array analysis, Molecular imaging, Prostate cancer",

author = "Cynthia M{\'e}nard and Susil, {Robert C.} and Peter Choyke and Jonathan Coleman and Robert Grubb and Ahmed Gharib and Axel Krieger and Peter Guion and David Thomasson and Karen Ullman and Sandeep Gupta and Virginia Espina and Lance Liotta and Emanuel Petricoin and Gabor Fitchtinger and Whitcomb, {Louis L.} and Ergin Atalar and {Norman Coleman}, C. and Kevin Camphausen",

year = "2005",

language = "English",

volume = "4",

pages = "63--66",

journal = "Molecular Imaging",

issn = "1535-3508",

publisher = "SAGE Publications Inc.",

number = "1",

}

Ménard, C, Susil, RC, Choyke, P, Coleman, J, Grubb, R, Gharib, A, Krieger, A, Guion, P, Thomasson, D, Ullman, K, Gupta, S, Espina, V, Liotta, L, Petricoin, E, Fitchtinger, G, Whitcomb, LL, Atalar, E, Norman Coleman, C & Camphausen, K 2005, 'An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement', Molecular Imaging, vol. 4, no. 1, pp. 63-66.

TY - JOUR

T1 - An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement

AU - Ménard, Cynthia

AU - Susil, Robert C.

AU - Choyke, Peter

AU - Coleman, Jonathan

AU - Grubb, Robert

AU - Gharib, Ahmed

AU - Krieger, Axel

AU - Guion, Peter

AU - Thomasson, David

AU - Ullman, Karen

AU - Gupta, Sandeep

AU - Espina, Virginia

AU - Liotta, Lance

AU - Petricoin, Emanuel

AU - Fitchtinger, Gabor

AU - Whitcomb, Louis L.

AU - Atalar, Ergin

AU - Norman Coleman, C.

AU - Camphausen, Kevin

PY - 2005

Y1 - 2005

N2 - The biological characterization of an individual patient's tumor by noninvasive Imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.

AB - The biological characterization of an individual patient's tumor by noninvasive Imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in patients with prostate cancer.

KW - Angiogenesis

KW - Interventional MRI

KW - Micro-array analysis

KW - Molecular imaging

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=23444455190&partnerID=8YFLogxK

M3 - Article

C2 - 15967127

AN - SCOPUS:23444455190

SN - 1535-3508

VL - 4

SP - 63

EP - 66

JO - Molecular Imaging

JF - Molecular Imaging

IS - 1

ER -

An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement

Abstract

Keywords

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