An overview of the translational dilemma and the need for translational systems biology of inflammation

Yoram Vodovotz*, Gary An

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


The translational dilemma, i.e., the difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes such as host-pathogen interactions. Despite numerous advances in defining novel molecules, pathways, and mechanisms, these advances remain, in general, in scientific silos that are poorly connected and lacking interoperability, reflected in the dearth of available therapeutics for these deadly diseases. We suggest that complex systems and computational biology methods and approaches have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. This book brings together the current state of the art in complex systems and computational biology as applied to inflammatory diseases.

Original languageEnglish
Title of host publicationComplex Systems and Computational Biology Approaches to Acute Inflammation
PublisherSpringer New York
Number of pages7
ISBN (Electronic)9781461480082
ISBN (Print)1461480078, 9781461480075
StatePublished - 1 May 2013
Externally publishedYes


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