TY - JOUR
T1 - Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer
AU - Welsh, John B.
AU - Sapinoso, Lisa M.
AU - Kern, Suzanne G.
AU - Hampton, Garret M.
AU - Su, Andrew I.
AU - Wang-Rodriguez, Jessica
AU - Moskaluk, Christopher A.
AU - Frierson, Henry F.
PY - 2001/8/15
Y1 - 2001/8/15
N2 - Detection, treatment, and prediction of outcome for men with prostate cancer increasingly depend on a molecular understanding of tumor development and behavior. We characterized primary prostate cancer by monitoring expression levels of more than 8900 genes in normal and malignant tissues. Patterns of gene expression across tissues revealed a precise distinction between normal and tumor samples, and revealed a striking group of about 400 genes that were overexpressed in tumor tissues. We ranked these genes according to their differential expression in normal and cancer tissues by selecting for highly and specifically overexpressed genes in the majority of cancers with correspondingly low or absent expression in normal tissues. Several such genes were identified that act within a variety of biochemical pathways and encode secreted molecules with diagnostic potential, such as the secreted macrophage inhibitory cytokine, MIC-1. Other genes, such as fatty acid synthase, encode enzymes known as drug targets in other contexts, which suggests new therapeutic approaches.
AB - Detection, treatment, and prediction of outcome for men with prostate cancer increasingly depend on a molecular understanding of tumor development and behavior. We characterized primary prostate cancer by monitoring expression levels of more than 8900 genes in normal and malignant tissues. Patterns of gene expression across tissues revealed a precise distinction between normal and tumor samples, and revealed a striking group of about 400 genes that were overexpressed in tumor tissues. We ranked these genes according to their differential expression in normal and cancer tissues by selecting for highly and specifically overexpressed genes in the majority of cancers with correspondingly low or absent expression in normal tissues. Several such genes were identified that act within a variety of biochemical pathways and encode secreted molecules with diagnostic potential, such as the secreted macrophage inhibitory cytokine, MIC-1. Other genes, such as fatty acid synthase, encode enzymes known as drug targets in other contexts, which suggests new therapeutic approaches.
UR - http://www.scopus.com/inward/record.url?scp=0035881732&partnerID=8YFLogxK
M3 - Article
C2 - 11507037
AN - SCOPUS:0035881732
SN - 0008-5472
VL - 61
SP - 5974
EP - 5978
JO - Cancer Research
JF - Cancer Research
IS - 16
ER -