Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors

Jing Zhou; Constance Brinckerhoff; Susan Lubert; Kui Yang; Jasmine Saini; Jeffrey Hooke; Richard Mural; Craig Shriver; Stella Somiari

doi:10.3109/07357907.2011.621915

Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors

Jing Zhou, Constance Brinckerhoff, Susan Lubert, Kui Yang, Jasmine Saini, Jeffrey Hooke, Richard Mural, Craig Shriver, Stella Somiari^*

^*Corresponding author for this work

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Abstract

A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.

Original language	English
Pages (from-to)	599-607
Number of pages	9
Journal	Cancer Investigation
Volume	29
Issue number	9
DOIs	https://doi.org/10.3109/07357907.2011.621915
State	Published - Nov 2011

Keywords

Breast cancers
Cancer biomarkers
Detection/diagnosis

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title = "Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors",

abstract = "A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.",

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AU - Zhou, Jing

AU - Brinckerhoff, Constance

AU - Lubert, Susan

AU - Yang, Kui

AU - Saini, Jasmine

AU - Hooke, Jeffrey

AU - Mural, Richard

AU - Shriver, Craig

AU - Somiari, Stella

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AB - A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.

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Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors

Abstract

Keywords

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