Analysis of temporal dynamics in imagery during acute limb ischemia and reperfusion

John M. Irvine, John Regan, Tammy A. Spain, Joseph D. Caruso, Maricela Rodriquez, Rajiv Luthra, Jonathon Forsberg, Nicole J. Crane, Eric Elster

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Ischemia and reperfusion injuries present major challenges for both military and civilian medicine. Improved methods for assessing the effects and predicting outcome could guide treatment decisions. Specific issues related to ischemia and reperfusion injury can include complications arising from tourniquet use, such as microvascular leakage in the limb, loss of muscle strength and systemic failures leading to hypotension and cardiac failure. Better methods for assessing the viability of limbs/tissues during ischemia and reducing complications arising from reperfusion are critical to improving clinical outcomes for at-risk patients. The purpose of this research is to develop and assess possible prediction models of outcome for acute limb ischemia using a pre-clinical model. Our model relies only on non-invasive imaging data acquired from an animal study. Outcome is measured by pathology and functional scores. We explore color, texture, and temporal features derived from both color and thermal motion imagery acquired during ischemia and reperfusion. The imagery features form the explanatory variables in a model for predicting outcome. Comparing model performance to outcome prediction based on direct observation of blood chemistry, blood gas, urinalysis, and physiological measurements provides a reference standard. Initial results show excellent performance for the imagery-base model, compared to predictions based direct measurements. This paper will present the models and supporting analysis, followed by recommendations for future investigations.

Original languageEnglish
Title of host publicationMedical Imaging 2014
Subtitle of host publicationImage Perception, Observer Performance, and Technology Assessment
ISBN (Print)9780819498304
StatePublished - 2014
Externally publishedYes
EventMedical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment - San Diego, CA, United States
Duration: 16 Feb 201417 Feb 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2014: Image Perception, Observer Performance, and Technology Assessment
Country/TerritoryUnited States
CitySan Diego, CA


  • Imagery
  • Ischemia
  • Outcome prediction
  • Reperfusion
  • Thermal imaging


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