Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi; Dennis J. Grab; J. Stephen Dumler

doi:10.1128/IAI.72.6.3680-3683.2004

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Kyoung Seong Choi, Dennis J. Grab, J. Stephen Dumler^*

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

Original language	English
Pages (from-to)	3680-3683
Number of pages	4
Journal	Infection and Immunity
Volume	72
Issue number	6
DOIs	https://doi.org/10.1128/IAI.72.6.3680-3683.2004
State	Published - Jun 2004

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10.1128/IAI.72.6.3680-3683.2004

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title = "Anaplasma phagocytophilum infection induces protracted neutrophil degranulation",

abstract = "Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.",

author = "Choi, \{Kyoung Seong\} and Grab, \{Dennis J.\} and Dumler, \{J. Stephen\}",

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AU - Choi, Kyoung Seong

AU - Grab, Dennis J.

AU - Dumler, J. Stephen

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N2 - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

AB - Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for ≥18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.

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SP - 3680

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JO - Infection and Immunity

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ER -

Anaplasma phagocytophilum infection induces protracted neutrophil degranulation

Abstract

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