Animal models for the study of military-related, blast-induced traumatic brain injury

Joseph T. McCabe; Chantal Moratz; Yunbo Liu; Ryan Egan; Hua Zhen Chen; Jiong Liu; Craig S. Budinich; Ellen E. Burton; Jonathan K. Danquah; Matthew R. Myers

doi:10.1109/BSEC.2010.5510803

Animal models for the study of military-related, blast-induced traumatic brain injury

Joseph T. McCabe
, Chantal Moratz
, Yunbo Liu
, Ryan Egan
, Hua Zhen Chen
, Jiong Liu
, Craig S. Budinich
, Ellen E. Burton
, Jonathan K. Danquah
, Matthew R. Myers

Anatomy, Physiology, and Genetics

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

In present war time conditions, traumatic brain injury (TBI) has moved to the forefront as a "signature injury." In terms of prevalence and understanding the biological mechanisms that underlie the injury, blast-induced TBI - particularly in "mild" cases - has proven to be a significant challenge for military medicine. Basic research that employs animal models of TBI is a key element for furthering our understanding of the biological consequences of blast-related TBI and for the development of therapeutic approaches. This paper outlines the currently available prototypes for the study of TBI, particularly in rodent models, and how the most widely used approaches for modeling TBI can contribute to understanding the mechanisms of injury.

Original language	English
Title of host publication	Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010
Subtitle of host publication	Biomedical Research and Analysis in Neuroscience, BRAiN
DOIs	https://doi.org/10.1109/BSEC.2010.5510803
State	Published - 2010
Event	2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN - Oak Ridge, TN, United States Duration: 25 May 2010 → 26 May 2010

Publication series

Name	Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN

Conference

Conference	2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN
Country/Territory	United States
City	Oak Ridge, TN
Period	25/05/10 → 26/05/10

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10.1109/BSEC.2010.5510803

Cite this

McCabe, J. T., Moratz, C., Liu, Y., Egan, R., Chen, H. Z., Liu, J., Budinich, C. S., Burton, E. E., Danquah, J. K., & Myers, M. R. (2010). Animal models for the study of military-related, blast-induced traumatic brain injury. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN Article 5510803 (Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN). https://doi.org/10.1109/BSEC.2010.5510803

McCabe, Joseph T. ; Moratz, Chantal ; Liu, Yunbo et al. / Animal models for the study of military-related, blast-induced traumatic brain injury. Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. (Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN).

@inproceedings{65229c4bcb154d4d88279857546cd3c4,

title = "Animal models for the study of military-related, blast-induced traumatic brain injury",

abstract = "In present war time conditions, traumatic brain injury (TBI) has moved to the forefront as a {"}signature injury.{"} In terms of prevalence and understanding the biological mechanisms that underlie the injury, blast-induced TBI - particularly in {"}mild{"} cases - has proven to be a significant challenge for military medicine. Basic research that employs animal models of TBI is a key element for furthering our understanding of the biological consequences of blast-related TBI and for the development of therapeutic approaches. This paper outlines the currently available prototypes for the study of TBI, particularly in rodent models, and how the most widely used approaches for modeling TBI can contribute to understanding the mechanisms of injury.",

author = "McCabe, \{Joseph T.\} and Chantal Moratz and Yunbo Liu and Ryan Egan and Chen, \{Hua Zhen\} and Jiong Liu and Budinich, \{Craig S.\} and Burton, \{Ellen E.\} and Danquah, \{Jonathan K.\} and Myers, \{Matthew R.\}",

year = "2010",

doi = "10.1109/BSEC.2010.5510803",

language = "English",

isbn = "9781424467143",

series = "Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN",

booktitle = "Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010",

note = "2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN ; Conference date: 25-05-2010 Through 26-05-2010",

}

McCabe, JT, Moratz, C, Liu, Y, Egan, R, Chen, HZ, Liu, J, Budinich, CS, Burton, EE, Danquah, JK & Myers, MR 2010, Animal models for the study of military-related, blast-induced traumatic brain injury. in Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN., 5510803, Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN, 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN, Oak Ridge, TN, United States, 25/05/10. https://doi.org/10.1109/BSEC.2010.5510803

Animal models for the study of military-related, blast-induced traumatic brain injury. / McCabe, Joseph T.; Moratz, Chantal; Liu, Yunbo et al.
Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510803 (Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Animal models for the study of military-related, blast-induced traumatic brain injury

AU - McCabe, Joseph T.

AU - Moratz, Chantal

AU - Liu, Yunbo

AU - Egan, Ryan

AU - Chen, Hua Zhen

AU - Liu, Jiong

AU - Budinich, Craig S.

AU - Burton, Ellen E.

AU - Danquah, Jonathan K.

AU - Myers, Matthew R.

PY - 2010

Y1 - 2010

N2 - In present war time conditions, traumatic brain injury (TBI) has moved to the forefront as a "signature injury." In terms of prevalence and understanding the biological mechanisms that underlie the injury, blast-induced TBI - particularly in "mild" cases - has proven to be a significant challenge for military medicine. Basic research that employs animal models of TBI is a key element for furthering our understanding of the biological consequences of blast-related TBI and for the development of therapeutic approaches. This paper outlines the currently available prototypes for the study of TBI, particularly in rodent models, and how the most widely used approaches for modeling TBI can contribute to understanding the mechanisms of injury.

AB - In present war time conditions, traumatic brain injury (TBI) has moved to the forefront as a "signature injury." In terms of prevalence and understanding the biological mechanisms that underlie the injury, blast-induced TBI - particularly in "mild" cases - has proven to be a significant challenge for military medicine. Basic research that employs animal models of TBI is a key element for furthering our understanding of the biological consequences of blast-related TBI and for the development of therapeutic approaches. This paper outlines the currently available prototypes for the study of TBI, particularly in rodent models, and how the most widely used approaches for modeling TBI can contribute to understanding the mechanisms of injury.

UR - https://www.scopus.com/pages/publications/77955596304

U2 - 10.1109/BSEC.2010.5510803

DO - 10.1109/BSEC.2010.5510803

M3 - Conference contribution

AN - SCOPUS:77955596304

SN - 9781424467143

T3 - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN

BT - Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010

T2 - 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN

Y2 - 25 May 2010 through 26 May 2010

ER -

McCabe JT, Moratz C, Liu Y, Egan R, Chen HZ, Liu J et al. Animal models for the study of military-related, blast-induced traumatic brain injury. In Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN. 2010. 5510803. (Proceedings of the 2010 Biomedical Science and Engineering Conference, BSEC 2010: Biomedical Research and Analysis in Neuroscience, BRAiN). doi: 10.1109/BSEC.2010.5510803

Animal models for the study of military-related, blast-induced traumatic brain injury

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