TY - JOUR
T1 - Anti-restenotic effect of copper-62 liquid-filled balloon in porcine coronary arteries
T2 - Novel use of a short half-life positron emitter
AU - Chan, Rosanna C.
AU - Lacy, Jeffrey L.
AU - Bhargava, Bairam
AU - Collins, Sara D.
AU - Gates, Pamela
AU - Cottin, Yves
AU - Kollum, Marc
AU - Yang, Nathan
AU - Haynes, Neal G.
AU - Martin, Christopher S.
AU - Nayak, Nisha
AU - Vodovotz, Yoram
AU - Kim, Han Soo
AU - Waksman, Ron
N1 - Funding Information:
Supported by DHHS (NIH, NCI) Grant 1R43CA81349-01.
PY - 2000
Y1 - 2000
N2 - Purpose: To determine the efficacy of the use of copper-62, a positron emitter with a half-life of 9.7 minutes, as an intracoronary brachytherapy (IRBT) source in the prevention of neointima formation (NF) following overstretch balloon injury (BI) in the porcine model. Methods and Materials: Sixteen swine were treated after BI to their left anterior descending (LAD), left circumflex (LCX), and/or right coronary artery (RCA). Twelve of the injured arteries received placebo and 10 received 25 Gy, delivered to 0.5 mm from the surface of the treatment balloon filled with liquid 62Cu. Dosimetry was based on Monte Carlo calculations. Two weeks after treatment, the animals were sacrificed, and the treated coronaries were perfusion-fixed and stained. Intimal area (IA) and medial fracture length (FL) were analyzed by computer-aided histomorphometry. Results: The (62Zn/62Cu) generator, together with a rapid concentration process, was successful in delivering the short-lived 62Cu at the high concentration required for intravascular brachytherapy (IVBT). The fracture length in the two groups was similar (2.10 ± 0.57; 2.02 ± 0.77; p = NS). Arteries studied showed significant reduction in NF (IA: 0.23 ± 0.47 mm2 vs. 1.08 ± 0.57 mm2; p < 0.01. IA/FL = 0.09 ± 0.17 mm vs. 0.51 ± 0.21 mm; p < 0.01). Conclusions: This study demonstrated that use of liquid 62Cu as an IVBT source is safe and feasible. All 16 swine tolerated the treatment well with no radiation-induced side effects or symptoms throughout the 2-week period. The isotope delivered the dose necessary to inhibit NF in the porcine coronary BI model.
AB - Purpose: To determine the efficacy of the use of copper-62, a positron emitter with a half-life of 9.7 minutes, as an intracoronary brachytherapy (IRBT) source in the prevention of neointima formation (NF) following overstretch balloon injury (BI) in the porcine model. Methods and Materials: Sixteen swine were treated after BI to their left anterior descending (LAD), left circumflex (LCX), and/or right coronary artery (RCA). Twelve of the injured arteries received placebo and 10 received 25 Gy, delivered to 0.5 mm from the surface of the treatment balloon filled with liquid 62Cu. Dosimetry was based on Monte Carlo calculations. Two weeks after treatment, the animals were sacrificed, and the treated coronaries were perfusion-fixed and stained. Intimal area (IA) and medial fracture length (FL) were analyzed by computer-aided histomorphometry. Results: The (62Zn/62Cu) generator, together with a rapid concentration process, was successful in delivering the short-lived 62Cu at the high concentration required for intravascular brachytherapy (IVBT). The fracture length in the two groups was similar (2.10 ± 0.57; 2.02 ± 0.77; p = NS). Arteries studied showed significant reduction in NF (IA: 0.23 ± 0.47 mm2 vs. 1.08 ± 0.57 mm2; p < 0.01. IA/FL = 0.09 ± 0.17 mm vs. 0.51 ± 0.21 mm; p < 0.01). Conclusions: This study demonstrated that use of liquid 62Cu as an IVBT source is safe and feasible. All 16 swine tolerated the treatment well with no radiation-induced side effects or symptoms throughout the 2-week period. The isotope delivered the dose necessary to inhibit NF in the porcine coronary BI model.
KW - Hyperplasia
KW - Intravascular brachytherapy
KW - Liquid-filled balloon
KW - Positron emitter
UR - http://www.scopus.com/inward/record.url?scp=0034264597&partnerID=8YFLogxK
U2 - 10.1016/S0360-3016(00)00649-0
DO - 10.1016/S0360-3016(00)00649-0
M3 - Article
C2 - 10974479
AN - SCOPUS:0034264597
SN - 0360-3016
VL - 48
SP - 583
EP - 592
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 2
ER -