Anti-restenotic effect of copper-62 liquid-filled balloon in porcine coronary arteries: Novel use of a short half-life positron emitter

Rosanna C. Chan, Jeffrey L. Lacy, Bairam Bhargava, Sara D. Collins, Pamela Gates, Yves Cottin, Marc Kollum, Nathan Yang, Neal G. Haynes, Christopher S. Martin, Nisha Nayak, Yoram Vodovotz, Han Soo Kim, Ron Waksman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose: To determine the efficacy of the use of copper-62, a positron emitter with a half-life of 9.7 minutes, as an intracoronary brachytherapy (IRBT) source in the prevention of neointima formation (NF) following overstretch balloon injury (BI) in the porcine model. Methods and Materials: Sixteen swine were treated after BI to their left anterior descending (LAD), left circumflex (LCX), and/or right coronary artery (RCA). Twelve of the injured arteries received placebo and 10 received 25 Gy, delivered to 0.5 mm from the surface of the treatment balloon filled with liquid 62Cu. Dosimetry was based on Monte Carlo calculations. Two weeks after treatment, the animals were sacrificed, and the treated coronaries were perfusion-fixed and stained. Intimal area (IA) and medial fracture length (FL) were analyzed by computer-aided histomorphometry. Results: The (62Zn/62Cu) generator, together with a rapid concentration process, was successful in delivering the short-lived 62Cu at the high concentration required for intravascular brachytherapy (IVBT). The fracture length in the two groups was similar (2.10 ± 0.57; 2.02 ± 0.77; p = NS). Arteries studied showed significant reduction in NF (IA: 0.23 ± 0.47 mm2 vs. 1.08 ± 0.57 mm2; p < 0.01. IA/FL = 0.09 ± 0.17 mm vs. 0.51 ± 0.21 mm; p < 0.01). Conclusions: This study demonstrated that use of liquid 62Cu as an IVBT source is safe and feasible. All 16 swine tolerated the treatment well with no radiation-induced side effects or symptoms throughout the 2-week period. The isotope delivered the dose necessary to inhibit NF in the porcine coronary BI model.

Original languageEnglish
Pages (from-to)583-592
Number of pages10
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number2
StatePublished - 2000
Externally publishedYes


  • Hyperplasia
  • Intravascular brachytherapy
  • Liquid-filled balloon
  • Positron emitter


Dive into the research topics of 'Anti-restenotic effect of copper-62 liquid-filled balloon in porcine coronary arteries: Novel use of a short half-life positron emitter'. Together they form a unique fingerprint.

Cite this