@article{bbfaa4ca8c5148c09e74a0e45be51532,
title = "Antimicrobial susceptibility trends among Escherichia coli and Shigella spp. isolated from rural Egyptian paediatric populations with diarrhoea between 1995 and 2000",
abstract = "Antimicrobial susceptibility testing was performed on 3627 isolates of Escherichia coli and 180 isolates of Shigella spp. collected in rural locations from 875 Egyptian children with diarrhoea between 1995 and 2000. The cumulative rates of resistance for E. coli and Shigella spp. were high (respectively, 68.2% and 54.8% for ampicillin, 24.2% and 23.5% for ampicillin-sulbactam, 57.2% and 42.5% for trimethoprim-sulphamethoxazole, and 50.9% and 75.4% for tetracycline). Non-enterotoxigenic E. coli (NETEC) isolates had a consistently higher level of antimicrobial resistance than did enterotoxigenic E. coli (ETEC) isolates. Trend testing showed significant decreases in resistance to ampicillin, ampicillin-sulbactam and tetracycline among all E. coli isolates. Increasing rates of resistance were observed for trimethoprim-sulphamethoxazole in ETEC isolates and Shigella spp., but not in NETEC isolates. Low levels of resistance were observed for all other antimicrobial agents tested. Overall, high levels, but decreasing trends, of resistance to commonly used antimicrobial agents were detected among isolates of E. coli and Shigella spp. from children in rural Egypt.",
keywords = "Antibiotic resistance, Diarrhoea, Egypt, Escherichia coli, Resistance, Shigella spp.",
author = "Putnam, {S. D.} and Riddle, {M. S.} and Wierzba, {T. F.} and Pittner, {B. T.} and Elyazeed, {R. A.} and A. El-Gendy and Rao, {M. R.} and Clemens, {J. D.} and Frenck, {R. W.}",
note = "Funding Information: The authors gratefully acknowledge funding provided by the DOD-GEIS program in conjunction with the Enterics Research Program of the US Navy, as well as support from the Naval Medical Research and Development Command (Work Unit Nos. M00101.HIX.3421 and M00101.PIX.3270), the National Institute of Child Health and Human Development (Interagency Agreement Y1-HD-0026-01), the World Health Organization Global Programme for Vaccines and Immunisation, and the World Health Organization Control of Diarrhoeal Diseases Programme. The authors also wish to thank the Enteric Disease Research Program at NAMRU-3, and B. Morsy (Director, Ministry of Health and Population, Abu Homos District) for her continued enthusiastic support. The opinions and assertions contained herein are those of the authors and are not to be construed as official or as reflecting the views of the US Department of the Navy, US Department of Defense, US Government, World Health Organization or Egyptian Ministry of Health.",
year = "2004",
month = sep,
doi = "10.1111/j.1469-0691.2004.00927.x",
language = "English",
volume = "10",
pages = "804--810",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier B.V.",
number = "9",
}