Antimicrobial susceptibility trends in Campylobacter jejuni and Campylobacter coli isolated from a rural Egyptian pediatric population with diarrhea

Shannon D. Putnam*, Robert W. Frenck, Mark S. Riddle, Atef El-Gendy, Nancy N. Taha, Brian T. Pittner, Remon Abu-Elyazeed, Thomas F. Wierzba, Malla R. Rao, Stephen J. Savarino, John D. Clemens

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Comparative and trend analysis was conducted on annual prevalence of antimicrobial susceptibility among Campylobacter jejuni and Campylobacter coli recovered from rural Egyptian children from 1995 through 2000. C. jejuni and C. coli demonstrated significant decreasing trends in ciprofloxacin susceptibility over the study period (p < 0.001 for both). In general, C. coli demonstrated a higher degree of susceptibility than C. jejuni, however, there was no statistical difference (p = 0.2) comparing the linear trends over the duration of the study. There was no indication of frank macrolide (erythromycin or azithromycin) resistance among any Campylobacter. Moreover, there were statistically significant positive trends in both the MIC50 and MIC90 values for the erythromycin and azithromycin during the study period, suggesting a possible decreasing trend in susceptibility among Campylobacter. This study demonstrated that antimicrobial susceptibility in Campylobacter has significantly decreased from 1995 through 2000 among pediatric diarrhea cases in rural Egypt.

Original languageEnglish
Pages (from-to)601-608
Number of pages8
JournalDiagnostic Microbiology and Infectious Disease
Volume47
Issue number4
DOIs
StatePublished - Dec 2003
Externally publishedYes

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