Antioxidant vitamins and colorectal adenoma

Harry B. Burke, Maurizio Ponz de Leon, Luca Roncucci, Thomas H. Wroth, E. Robert Greenberg, John A. Baron, Tor D. Tosteson

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


Greenberg et al. (July 21 issue)1 report negative results when three antioxidant vitamins (beta carotene, vitamin C, and vitamin E) were given over a four-year period to test their efficacy in preventing colorectal adenoma, a surrogate outcome for colorectal cancer. The authors suggest that the three-year period between the colonoscopic examinations at year 1 and year 4 may not have been long enough for a change in the incidence of adenoma to be observed and that the interventions used may not have been the correct ones to reduce the incidence. A third explanation is that the interventions.  . .

Original languageEnglish
Pages (from-to)1720-1721
Number of pages2
JournalNew England Journal of Medicine
Issue number25
StatePublished - 22 Dec 1994
Externally publishedYes


Dive into the research topics of 'Antioxidant vitamins and colorectal adenoma'. Together they form a unique fingerprint.

Cite this