Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors)

Michael J Zapor, Kelly L Cozza, Gary H Wynn, Glenn W Wortmann, Scott C Armstrong

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

The second in a series reviewing the HIV/AIDS antiretroviral drugs. This review summarizes the non-protease inhibitor antiretrovirals: nucleoside and nucleotide analogue reverse transcriptase inhibitors (NRTIs), the nonnucleoside reverse transcriptase inhibitors (NNRTIs), and cell membrane fusion inhibitors. In an overview format for primary care physicians and psychiatrists, this review presents the mechanism of action, side effects, toxicities, and drug interactions of these agents.

Original languageEnglish
Pages (from-to)524-35
Number of pages12
JournalPsychosomatics
Volume45
Issue number6
DOIs
StatePublished - 2004

Keywords

  • Acquired Immunodeficiency Syndrome/drug therapy
  • Adenine/analogs & derivatives
  • Alkynes
  • Anti-Retroviral Agents/pharmacology
  • Benzoxazines
  • Cell Membrane Permeability/drug effects
  • Cyclopropanes
  • Delavirdine/therapeutic use
  • Deoxycytidine/analogs & derivatives
  • Didanosine/therapeutic use
  • Dideoxynucleosides/therapeutic use
  • Drug Interactions
  • Emtricitabine
  • HIV Fusion Inhibitors/therapeutic use
  • HIV Seropositivity/drug therapy
  • Humans
  • Lamivudine/therapeutic use
  • Nevirapine/therapeutic use
  • Organophosphonates/therapeutic use
  • Oxazines/therapeutic use
  • Reverse Transcriptase Inhibitors/pharmacology
  • Stavudine/therapeutic use
  • Tenofovir
  • Zalcitabine/therapeutic use
  • Zidovudine/therapeutic use

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