AP-2γ protein expression in intratubular germ cell neoplasma of testis

Seung Mo Hong, Henry F. Frierson, Christopher A. Moskaluk*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.

Original languageEnglish
Pages (from-to)873-877
Number of pages5
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - Dec 2005
Externally publishedYes


  • AP-2γ
  • Activator protein 2γ
  • Germ cell tumor
  • Immunohistochemistry
  • Intratubular neoplasia
  • Testis


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