TY - JOUR
T1 - AP-2γ protein expression in intratubular germ cell neoplasma of testis
AU - Hong, Seung Mo
AU - Frierson, Henry F.
AU - Moskaluk, Christopher A.
PY - 2005/12
Y1 - 2005/12
N2 - Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.
AB - Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.
KW - AP-2γ
KW - Activator protein 2γ
KW - Germ cell tumor
KW - Immunohistochemistry
KW - Intratubular neoplasia
KW - Testis
UR - http://www.scopus.com/inward/record.url?scp=85047693998&partnerID=8YFLogxK
U2 - 10.1309/6Q0JB9CCGRQ7RKCQ
DO - 10.1309/6Q0JB9CCGRQ7RKCQ
M3 - Article
C2 - 16416736
AN - SCOPUS:85047693998
SN - 0002-9173
VL - 124
SP - 873
EP - 877
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 6
ER -