AP-2γ protein expression in intratubular germ cell neoplasma of testis

Seung Mo Hong; Henry F. Frierson; Christopher A. Moskaluk

doi:10.1309/6Q0JB9CCGRQ7RKCQ

AP-2γ protein expression in intratubular germ cell neoplasma of testis

Seung Mo Hong, Henry F. Frierson, Christopher A. Moskaluk^*

^*Corresponding author for this work

Surgery

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12 Scopus citations

Abstract

Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.

Original language	English
Pages (from-to)	873-877
Number of pages	5
Journal	American Journal of Clinical Pathology
Volume	124
Issue number	6
DOIs	https://doi.org/10.1309/6Q0JB9CCGRQ7RKCQ
State	Published - Dec 2005

Keywords

AP-2γ
Activator protein 2γ
Germ cell tumor
Immunohistochemistry
Intratubular neoplasia
Testis

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title = "AP-2γ protein expression in intratubular germ cell neoplasma of testis",

abstract = "Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.",

keywords = "AP-2γ, Activator protein 2γ, Germ cell tumor, Immunohistochemistry, Intratubular neoplasia, Testis",

author = "Hong, {Seung Mo} and Frierson, {Henry F.} and Moskaluk, {Christopher A.}",

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journal = "American Journal of Clinical Pathology",

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TY - JOUR

T1 - AP-2γ protein expression in intratubular germ cell neoplasma of testis

AU - Hong, Seung Mo

AU - Frierson, Henry F.

AU - Moskaluk, Christopher A.

PY - 2005/12

Y1 - 2005/12

N2 - Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.

AB - Although activator protein 2γ(AP-2γ) has been reported to be a marker of germ cell tumors of the testis, its relationship to placental alkaline phosphatase (PLAP) and KIT (CD117) protein expression in intratubular germ cell neoplasia (ITGCN) has not been directly compared. In this study, staining of AP-2γ in 30 cases of ITGCN was examined and compared with that of PLAP and KIT. Both PLAP and KIT were positive in 29 (97%) of 30 cases, whereas AP-2γ was expressed in 100%. All 3 markers were negative in normal testis (0 of 11 cases). DNA binding sites in the promoter region for AP-2γ in the PLAP and c-kit genes might explain the concordance of protein expression.

KW - AP-2γ

KW - Activator protein 2γ

KW - Germ cell tumor

KW - Immunohistochemistry

KW - Intratubular neoplasia

KW - Testis

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JF - American Journal of Clinical Pathology

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AP-2γ protein expression in intratubular germ cell neoplasma of testis

Abstract

Keywords

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