Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis

Nicole Duster; Nanda Ramchandar; Jennifer Foley; Lauge Farnaes; Nicole G. Coufal

doi:10.1016/j.mimet.2023.106887

Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis

Nicole Duster, Nanda Ramchandar, Jennifer Foley, Lauge Farnaes, Nicole G. Coufal^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36% of 28 subjects, compared to 50% for diverse conventional testing (57% combined). CFPNGS may be considered as an adjunct to standard testing.

Original language	English
Article number	106887
Journal	Journal of Microbiological Methods
Volume	217-218
DOIs	https://doi.org/10.1016/j.mimet.2023.106887
State	Published - 1 Feb 2024

Keywords

Cell-free plasma sequencing
CNS infection
Meningitis
Metagenomics
NGS

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10.1016/j.mimet.2023.106887

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title = "Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis",

abstract = "This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36\% of 28 subjects, compared to 50\% for diverse conventional testing (57\% combined). CFPNGS may be considered as an adjunct to standard testing.",

keywords = "Cell-free plasma sequencing, CNS infection, Meningitis, Metagenomics, NGS",

author = "Nicole Duster and Nanda Ramchandar and Jennifer Foley and Lauge Farnaes and Coufal, \{Nicole G.\}",

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AU - Foley, Jennifer

AU - Farnaes, Lauge

AU - Coufal, Nicole G.

PY - 2024/2/1

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N2 - This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36% of 28 subjects, compared to 50% for diverse conventional testing (57% combined). CFPNGS may be considered as an adjunct to standard testing.

AB - This retrospective study evaluates the clinical utility of CFPNGS in the diagnosis and management of pediatric meningitis. CFPNGS identified a causative pathogen in 36% of 28 subjects, compared to 50% for diverse conventional testing (57% combined). CFPNGS may be considered as an adjunct to standard testing.

KW - Cell-free plasma sequencing

KW - CNS infection

KW - Meningitis

KW - Metagenomics

KW - NGS

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Application of cell-free plasma next-generation sequencing technology in the diagnosis and management of pediatric meningitis

Abstract

Keywords

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