Apyrase elicits host antimicrobial responses and resolves infection in burns

Jill M. Bayliss, Benjamin Levi, Jianfeng Wu, Stewart C. Wang, Grace L. Su, Chuanwu Xi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The authors previously reported that adenosine triphosphate (ATP) stimulates biofilm formation and removal of the ATP could reduce biofilm formation. The main objective of this study was to evaluate the effects of the ATP-hydrolyzing enzyme, apyrase, on control of Acinetabacter baumannii infection in the burn wound as well as to assess host skin antimicrobial responses. The authors found that apyrase stimulated nitric oxide formation at the wound site and reduced CD55 expression, thereby inducing the assembly of membrane attack complexes. Apyrase treatment nearly eradicated multidrug-resistant A. baumannii from burn wounds in the absence of antibiotics. Apyrase may be an effective therapy against antibiotic-resistant bacterial infections in burns.

Original languageEnglish
Pages (from-to)e501-e507
JournalJournal of Burn Care and Research
Issue number6
StatePublished - 2016
Externally publishedYes


Dive into the research topics of 'Apyrase elicits host antimicrobial responses and resolves infection in burns'. Together they form a unique fingerprint.

Cite this