Aspirin-exacerbated respiratory disease: Evaluation and management

Rachel U. Lee, Donald D. Stevenson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

185 Scopus citations


The clinical syndrome of aspirin-exacerbated respiratory disease (AERD) is a condition where inhibition of cyclooxygenase-1 (COX-1) induces attacks of upper and lower airway reactions, including rhinorrhea and varying degrees of bronchospasm and laryngospasm. Although the reaction is not IgEmediated, patients can also present with anaphylactic hypersensitivity reactions, including hypotension, after exposure to COX-1 inhibiting drugs. All patients with AERD have underlying nasal polyps and intractable sinus disease which may be difficult to treat with standard medical and surgical interventions. This review article focuses on the management of AERD patients with a particular emphasis on aspirin desensitization and continuous treatment with aspirin.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalAllergy, Asthma and Immunology Research
Issue number1
StatePublished - Dec 2010
Externally publishedYes


  • Aspirin desensitization
  • Aspirin sensitivity
  • Aspirin-exacerbated respiratory disease
  • Asthma
  • Chronic sinusitis
  • Nasal polyps
  • Samter's triad


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