Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Maunoo Lee; Jayasree Krishnamurthy; Apryl Susi; Carolyn Sullivan; Gregory H. Gorman; Elizabeth Hisle-Gorman; Christine R. Erdie-Lalena; Cade M. Nylund

doi:10.1007/s10803-017-3409-5

Association of Autism Spectrum Disorders and Inflammatory Bowel Disease

Maunoo Lee^*, Jayasree Krishnamurthy, Apryl Susi, Carolyn Sullivan, Gregory H. Gorman, Elizabeth Hisle-Gorman, Christine R. Erdie-Lalena, Cade M. Nylund

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn’s disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.

Original language	English
Pages (from-to)	1523-1529
Number of pages	7
Journal	Journal of autism and developmental disorders
Volume	48
Issue number	5
DOIs	https://doi.org/10.1007/s10803-017-3409-5
State	Published - 1 May 2018

Keywords

Autism spectrum disorders (ASD)
Crohn’s disease (CD)
Inflammatory bowel disease (IBD)
Ulcerative colitis (UC)

Access to Document

10.1007/s10803-017-3409-5

Cite this

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title = "Association of Autism Spectrum Disorders and Inflammatory Bowel Disease",

abstract = "Autism spectrum disorders (ASD) and inflammatory bowel disease (IBD) both have multifactorial pathogenesis with an increasing number of studies demonstrating gut-brain associations. We aim to examine the association between ASD and IBD using strict classification criteria for IBD. We conducted a retrospective case-cohort study using records from the Military Health System database with IBD defined as having one encounter with an ICD-9-CM diagnostic code for IBD and at least one outpatient prescription dispensed for a medication to treat IBD. Children with ASD were more likely to meet criteria for Crohn{\textquoteright}s disease (CD) and Ulcerative colitis (UC) compared to controls. This higher prevalence of CD and UC in children with ASD compared to controls confirms the association of ASD with IBD.",

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AU - Erdie-Lalena, Christine R.

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