TY - JOUR
T1 - Association of Bartonella species and Coxiella burnetii infection with coronary artery disease
AU - Ender, Peter T.
AU - Phares, Joel
AU - Gerson, Gordon
AU - Taylor, Stacie E.
AU - Regnery, Russell
AU - Challener, Roberta C.
AU - Dolan, Matthew J.
N1 - Funding Information:
The views expressed here are those of the authors and do not reflect the official policy or position of the US Air Force, US Department of Defense, or US government. Financial support: US Department of Defense.
PY - 2001/3/1
Y1 - 2001/3/1
N2 - Coronary artery disease is an inflammatory condition associated with several infections. We prospectively evaluated 155 consecutive patients undergoing coronary angiography for evidence of Bartonella species and Coxiella burnetii infection. All Bartonella cultures were found to be negative. Multivariable logistic regression analysis that controlled for potential confounding factors revealed no association between coronary artery disease and seropositivity to Bartonella henselae (odds ratio [OR], 0.852; 95% confidence interval [CI], 0.293-2.476), Bartonella quintana (OR, 0.425; 95% CI, 0.127-1.479), C. burnetii phase 1 (OR, undefined), and C. burnetii phase 2 (OR, 0.731; 95% CI, 0.199-2.680). The geometric mean titer (GMT) for C. burnetii phase 1 assay was slightly higher in persons with coronary artery disease than in those without such disease (P < .02). B. henselae, B. quintana, and C. burnetii seropositivity was not strongly associated with coronary artery disease. On the basis of GMTs, C. burnetii infection may have a modest association with coronary artery disease.
AB - Coronary artery disease is an inflammatory condition associated with several infections. We prospectively evaluated 155 consecutive patients undergoing coronary angiography for evidence of Bartonella species and Coxiella burnetii infection. All Bartonella cultures were found to be negative. Multivariable logistic regression analysis that controlled for potential confounding factors revealed no association between coronary artery disease and seropositivity to Bartonella henselae (odds ratio [OR], 0.852; 95% confidence interval [CI], 0.293-2.476), Bartonella quintana (OR, 0.425; 95% CI, 0.127-1.479), C. burnetii phase 1 (OR, undefined), and C. burnetii phase 2 (OR, 0.731; 95% CI, 0.199-2.680). The geometric mean titer (GMT) for C. burnetii phase 1 assay was slightly higher in persons with coronary artery disease than in those without such disease (P < .02). B. henselae, B. quintana, and C. burnetii seropositivity was not strongly associated with coronary artery disease. On the basis of GMTs, C. burnetii infection may have a modest association with coronary artery disease.
UR - http://www.scopus.com/inward/record.url?scp=0035282651&partnerID=8YFLogxK
U2 - 10.1086/318831
DO - 10.1086/318831
M3 - Article
C2 - 11181164
AN - SCOPUS:0035282651
SN - 0022-1899
VL - 183
SP - 831
EP - 834
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -