Association of Traumatic Brain Injury and Glioblastoma Multiforme: A Case Series

Joseph An*, Emily Freeman, Ian J. Stewart*, Michael Dore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Glioblastoma multiforme (GBM) is an aggressive variant of central nervous system gliomas that carries a dismal prognosis. Although GBM is the most frequently occurring and malignant type of glioma accounting for more than 60% of all brain tumors in adults, its overall incidence is rare, occurring at a rate of 3.21 per 100,000 persons. Little is known about the etiology of GBM, but one proposed theory is that GBM pathogenesis may be linked to a chronic inflammatory course initiated by traumatic injury to the brain. Limited case reports have suggested an association between GBMs and traumatic brain injury (TBI), but larger case-control and epidemiologic studies have been inconclusive. We present three service members (two active duty and one retired) who developed GBM near the original site of prior head trauma. Each service member's military occupation was in the special operations community and shared a common theme of TBI following head trauma/injury. The current research on the association between TBI and GBM is limited and conflicting, predominantly due to the low incidence of the disease in the general population. Evidence has indicated that TBI should be considered a chronic disease with long-term health impacts, including long-term disability, dementia, epilepsy, mental health conditions, and cardiovascular diseases. With the addition of our patients, as well as a recently published study proposing a molecular association between trauma and GBM, further research is needed to better understand the potential relationship.

Original languageEnglish
Pages (from-to)E27-E33
JournalMilitary Medicine
Issue number1-2
StatePublished - 1 Jan 2024
Externally publishedYes


Dive into the research topics of 'Association of Traumatic Brain Injury and Glioblastoma Multiforme: A Case Series'. Together they form a unique fingerprint.

Cite this