TY - JOUR
T1 - Asymptomatic lymphogranuloma venereum among Nigerian men who have sex with men
AU - TRUST/RV368 Study Group
AU - Crowell, Trevor A.
AU - Hardick, Justin
AU - Lombardi, Kara
AU - Parker, Zahra
AU - Kokogho, Afoke
AU - Amusu, Senate
AU - Odeyemi, Sunday
AU - Ivo, Andrew
AU - Baral, Stefan D.
AU - Nowak, Rebecca G.
AU - Adebajo, Sylvia
AU - Charurat, Manhattan E.
AU - Ake, Julie
AU - Gaydos, Charlotte A.
N1 - Publisher Copyright:
© 2018 Article author(s). All rights reserved.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Objectives: Recent outbreaks of anorectal lymphogranuloma venereum (LGV) among men who have sex with men (MSM) have been characterised by proctocolitis requiring extended antibiotic treatment compared with infections caused by other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT. Methods: MSM were recruited for this observational cohort in Lagos, Nigeria, using respondent-driven sampling and screened for HIV and bacterial STIs every three months for up to 18 months. Nucleic acid amplification tests for CT were performed on rectal swab specimens. Prevalent and incident cases of anorectal CT underwent additional testing to identify LGV using novel real-time PCR assays specific for the L-serovars of CT. Results: From April 2014 to July 2016, 420 MSM underwent testing for rectal STIs, of whom 66 (15.7%) had prevalent anorectal CT. Among those without prevalent disease, 68 developed incident infections during 208 person-years of follow-up. Of 134 prevalent and incident cases of anorectal CT, 7 (5.2%) were identified as LGV. None of the seven participants with LGV reported any symptoms. Two of the participants with LGV were simultaneously coinfected with rectal gonorrhoea. HIV coinfection was common among participants with both LGV (n=5, 71%) and non-LGV (n=98, 77%) serovars of CT (P=0.66). Conclusions: Anorectal LGV was uncommon but present among Nigerian MSM in this study. Consistent screening for L-serovars of CT, or presumptive treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission.
AB - Objectives: Recent outbreaks of anorectal lymphogranuloma venereum (LGV) among men who have sex with men (MSM) have been characterised by proctocolitis requiring extended antibiotic treatment compared with infections caused by other serovars of Chlamydia trachomatis (CT). We describe the prevalence and clinical features of LGV among Nigerian MSM diagnosed with anorectal CT. Methods: MSM were recruited for this observational cohort in Lagos, Nigeria, using respondent-driven sampling and screened for HIV and bacterial STIs every three months for up to 18 months. Nucleic acid amplification tests for CT were performed on rectal swab specimens. Prevalent and incident cases of anorectal CT underwent additional testing to identify LGV using novel real-time PCR assays specific for the L-serovars of CT. Results: From April 2014 to July 2016, 420 MSM underwent testing for rectal STIs, of whom 66 (15.7%) had prevalent anorectal CT. Among those without prevalent disease, 68 developed incident infections during 208 person-years of follow-up. Of 134 prevalent and incident cases of anorectal CT, 7 (5.2%) were identified as LGV. None of the seven participants with LGV reported any symptoms. Two of the participants with LGV were simultaneously coinfected with rectal gonorrhoea. HIV coinfection was common among participants with both LGV (n=5, 71%) and non-LGV (n=98, 77%) serovars of CT (P=0.66). Conclusions: Anorectal LGV was uncommon but present among Nigerian MSM in this study. Consistent screening for L-serovars of CT, or presumptive treatment for LGV in cases with a high suspicion for this diagnosis, could potentially improve patient outcomes and decrease transmission.
KW - Africa
KW - HIV
KW - chlamydia trachomatis
KW - lymphogranuloma venereum
KW - men who have sex with men
KW - sexually transmitted infection
UR - http://www.scopus.com/inward/record.url?scp=85049117042&partnerID=8YFLogxK
U2 - 10.1136/sextrans-2017-053414
DO - 10.1136/sextrans-2017-053414
M3 - Article
C2 - 29378902
AN - SCOPUS:85049117042
SN - 1368-4973
VL - 94
SP - 578
EP - 581
JO - Sexually Transmitted Infections
JF - Sexually Transmitted Infections
IS - 8
ER -