Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Peifang Sun; Irene Ramos; Camila H. Coelho; Alba Grifoni; Corey A. Balinsky; Sindhu Vangeti; Alison Tarke; Nathaniel I. Bloom; Vihasi Jani; Silvia J. Jakubski; David A. Boulifard; Elizabeth Cooper; Carl W. Goforth; Jan Marayag; Amethyst Marrone; Edgar Nunez; Lindsey White; Chad K. Porter; Victor A. Sugiharto; Megan Schilling; Avinash S. Mahajan; Charmagne Beckett; Alessandro Sette; Stuart C. Sealfon; Shane Crotty; Andrew G. Letizia

doi:10.1016/j.isci.2022.105202

Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Peifang Sun, Irene Ramos, Camila H. Coelho, Alba Grifoni, Corey A. Balinsky, Sindhu Vangeti, Alison Tarke, Nathaniel I. Bloom, Vihasi Jani, Silvia J. Jakubski, David A. Boulifard, Elizabeth Cooper, Carl W. Goforth, Jan Marayag, Amethyst Marrone, Edgar Nunez, Lindsey White, Chad K. Porter, Victor A. Sugiharto, Megan SchillingAvinash S. Mahajan, Charmagne Beckett, Alessandro Sette, Stuart C. Sealfon^*, Shane Crotty^*, Andrew G. Letizia^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.

Original language	English
Article number	105202
Journal	iScience
Volume	25
Issue number	10
DOIs	https://doi.org/10.1016/j.isci.2022.105202
State	Published - 21 Oct 2022
Externally published	Yes

Keywords

Biological sciences
immunology
microbiology

Access to Document

10.1016/j.isci.2022.105202

Cite this

Sun, P., Ramos, I., Coelho, C. H., Grifoni, A., Balinsky, C. A., Vangeti, S., Tarke, A., Bloom, N. I., Jani, V., Jakubski, S. J., Boulifard, D. A., Cooper, E., Goforth, C. W., Marayag, J., Marrone, A., Nunez, E., White, L., Porter, C. K., Sugiharto, V. A., ... Letizia, A. G. (2022). Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern. iScience, 25(10), Article 105202. https://doi.org/10.1016/j.isci.2022.105202

@article{0388345a79a9477eaf79b1c2cfdbd86c,

title = "Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern",

abstract = "The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.",

keywords = "Biological sciences, immunology, microbiology",

author = "Peifang Sun and Irene Ramos and Coelho, {Camila H.} and Alba Grifoni and Balinsky, {Corey A.} and Sindhu Vangeti and Alison Tarke and Bloom, {Nathaniel I.} and Vihasi Jani and Jakubski, {Silvia J.} and Boulifard, {David A.} and Elizabeth Cooper and Goforth, {Carl W.} and Jan Marayag and Amethyst Marrone and Edgar Nunez and Lindsey White and Porter, {Chad K.} and Sugiharto, {Victor A.} and Megan Schilling and Mahajan, {Avinash S.} and Charmagne Beckett and Alessandro Sette and Sealfon, {Stuart C.} and Shane Crotty and Letizia, {Andrew G.}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = oct,

day = "21",

doi = "10.1016/j.isci.2022.105202",

language = "English",

volume = "25",

journal = "iScience",

issn = "2589-0042",

number = "10",

}

Sun, P, Ramos, I, Coelho, CH, Grifoni, A, Balinsky, CA, Vangeti, S, Tarke, A, Bloom, NI, Jani, V, Jakubski, SJ, Boulifard, DA, Cooper, E, Goforth, CW, Marayag, J, Marrone, A, Nunez, E, White, L, Porter, CK, Sugiharto, VA, Schilling, M, Mahajan, AS, Beckett, C, Sette, A, Sealfon, SC, Crotty, S & Letizia, AG 2022, 'Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern', iScience, vol. 25, no. 10, 105202. https://doi.org/10.1016/j.isci.2022.105202

TY - JOUR

T1 - Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

AU - Sun, Peifang

AU - Ramos, Irene

AU - Coelho, Camila H.

AU - Grifoni, Alba

AU - Balinsky, Corey A.

AU - Vangeti, Sindhu

AU - Tarke, Alison

AU - Bloom, Nathaniel I.

AU - Jani, Vihasi

AU - Jakubski, Silvia J.

AU - Boulifard, David A.

AU - Cooper, Elizabeth

AU - Goforth, Carl W.

AU - Marayag, Jan

AU - Marrone, Amethyst

AU - Nunez, Edgar

AU - White, Lindsey

AU - Porter, Chad K.

AU - Sugiharto, Victor A.

AU - Schilling, Megan

AU - Mahajan, Avinash S.

AU - Beckett, Charmagne

AU - Sette, Alessandro

AU - Sealfon, Stuart C.

AU - Crotty, Shane

AU - Letizia, Andrew G.

PY - 2022/10/21

Y1 - 2022/10/21

N2 - The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.

AB - The ongoing evolution of SARS-CoV-2 requires monitoring the capability of immune responses to cross-recognize Variants of Concern (VOC). In this cross-sectional study, we examined serological and cell-mediated immune memory to SARS-CoV-2 variants, including Omicron, among a cohort of 18-21-year-old Marines with a history of either asymptomatic or mild SARS-CoV-2 infection 6 to 14 months earlier. Among the 210 participants in the study, 169 were unvaccinated while 41 received 2 doses of mRNA-based COVID-19 vaccines. Vaccination of previously infected participants strongly boosted neutralizing and binding activity and memory B and T cell responses including the recognition of Omicron, compared to infected but unvaccinated participants. Additionally, no measurable differences were observed in immune memory in healthy young adults with previous symptomatic or asymptomatic infections, for ancestral or variant strains. These results provide mechanistic immunological insights into population-based differences observed in immunity against Omicron and other variants among individuals with different clinical histories.

KW - Biological sciences

KW - immunology

KW - microbiology

UR - http://www.scopus.com/inward/record.url?scp=85139400428&partnerID=8YFLogxK

U2 - 10.1016/j.isci.2022.105202

DO - 10.1016/j.isci.2022.105202

M3 - Article

AN - SCOPUS:85139400428

SN - 2589-0042

VL - 25

JO - iScience

JF - iScience

IS - 10

M1 - 105202

ER -

Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern

Abstract

Keywords

Access to Document

Fingerprint

Cite this