TY - JOUR
T1 - Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model
AU - Subramanian, Sreekumar
AU - Bowyer, Mark W.
AU - Egan, J. Craig
AU - Knolmayer, Thomas J.
N1 - Funding Information:
This work was supported by Grant SGO #96-079 from the United States Air Force Surgeon General’s Office.
PY - 1999/12
Y1 - 1999/12
N2 - Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury. Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05. Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin. Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model. Copyright (C) 1999 Excerpta Medica Inc.
AB - Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury. Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05. Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin. Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model. Copyright (C) 1999 Excerpta Medica Inc.
UR - http://www.scopus.com/inward/record.url?scp=0033399405&partnerID=8YFLogxK
U2 - 10.1016/S0002-9610(99)00238-X
DO - 10.1016/S0002-9610(99)00238-X
M3 - Article
C2 - 10670875
AN - SCOPUS:0033399405
SN - 0002-9610
VL - 178
SP - 573
EP - 575
JO - American Journal of Surgery
JF - American Journal of Surgery
IS - 6
ER -