Augmentation of human natural killer cells by splenopentin analogs

A. Rastogi; V. K. Singh; S. Biswas; W. Haq; K. B. Mathur; S. S. Agarwal

doi:10.1016/0014-5793(93)81498-O

Augmentation of human natural killer cells by splenopentin analogs

A. Rastogi
, V. K. Singh^*
, S. Biswas
, W. Haq
, K. B. Mathur
, S. S. Agarwal

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), d-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	FEBS Letters
Volume	317
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(93)81498-O
State	Published - 8 Feb 1993

Keywords

Immunomodulator
NK. cell cytotoxicity
Splenopentin
T-cell transformation
Thymopoietin

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title = "Augmentation of human natural killer cells by splenopentin analogs",

abstract = "Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), d-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.",

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author = "A. Rastogi and Singh, \{V. K.\} and S. Biswas and W. Haq and Mathur, \{K. B.\} and Agarwal, \{S. S.\}",

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doi = "10.1016/0014-5793(93)81498-O",

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TY - JOUR

T1 - Augmentation of human natural killer cells by splenopentin analogs

AU - Rastogi, A.

AU - Singh, V. K.

AU - Biswas, S.

AU - Haq, W.

AU - Mathur, K. B.

AU - Agarwal, S. S.

PY - 1993/2/8

Y1 - 1993/2/8

N2 - Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), d-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.

AB - Splenopentin, Arg-Lys-Glu-Val-Tyr (SP-5) and its synthetic analogs; Arg-d-Lys-Glu-Val-Tyr (pentapeptide 1), Lys-Lys-Glu-Val-Tyr (2), d-Lys-Lys-Glu-Val-Tyr (3), Arg-Lys-Gly-Val-Tyr (4), and Arg-Lys-Gln-Val-Tyr (5) have been examined for augmentation of human natural killer (NK) cell activity and human T-cell transformation response. Pentapeptides 2 and 3 were found to significantly augment the in vitro human NK cell activity. However, none of them had any effect on lymphocyte proliferative responses.

KW - Immunomodulator

KW - NK. cell cytotoxicity

KW - Splenopentin

KW - T-cell transformation

KW - Thymopoietin

UR - https://www.scopus.com/pages/publications/0027500526

U2 - 10.1016/0014-5793(93)81498-O

DO - 10.1016/0014-5793(93)81498-O

M3 - Article

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AN - SCOPUS:0027500526

SN - 0014-5793

VL - 317

SP - 93

EP - 95

JO - FEBS Letters

JF - FEBS Letters

IS - 1-2

ER -

Augmentation of human natural killer cells by splenopentin analogs

Abstract

Keywords

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