B-cell and T-cell function in systemic lupus erythematosus

C. S. Via; B. S. Handwerger

doi:10.1097/00002281-199305050-00004

B-cell and T-cell function in systemic lupus erythematosus

C. S. Via^*, B. S. Handwerger

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

The process of autoantibody production in systemic lupus erythematosus is characterized by findings of both an antigen-driven response and polyclonal B-cell activation. Autoantibody production does not appear to be critically dependent on the presence of the CD5$U+ B cell subset. Increasing evidence supports a role for T helper cell type 2 cytokines, such as interleukin-4 and interleukin-6, in promoting and perpetuating B-cell hyperactivity and autoantibody formation.

Original language	English
Pages (from-to)	570-574
Number of pages	5
Journal	Current Opinion in Rheumatology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1097/00002281-199305050-00004
State	Published - 1993

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10.1097/00002281-199305050-00004

Cite this

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title = "B-cell and T-cell function in systemic lupus erythematosus",

abstract = "The process of autoantibody production in systemic lupus erythematosus is characterized by findings of both an antigen-driven response and polyclonal B-cell activation. Autoantibody production does not appear to be critically dependent on the presence of the CD5$U+ B cell subset. Increasing evidence supports a role for T helper cell type 2 cytokines, such as interleukin-4 and interleukin-6, in promoting and perpetuating B-cell hyperactivity and autoantibody formation.",

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AB - The process of autoantibody production in systemic lupus erythematosus is characterized by findings of both an antigen-driven response and polyclonal B-cell activation. Autoantibody production does not appear to be critically dependent on the presence of the CD5$U+ B cell subset. Increasing evidence supports a role for T helper cell type 2 cytokines, such as interleukin-4 and interleukin-6, in promoting and perpetuating B-cell hyperactivity and autoantibody formation.

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