TY - JOUR
T1 - Basic science review on adipose tissue for clinicians
AU - Brown, Spencer A.
AU - Levi, Benjamin
AU - Lequex, Charlotte
AU - Wong, Victor W.
AU - Mojallal, Ali
AU - Longaker, Michael T.
PY - 2010/12
Y1 - 2010/12
N2 - The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell-based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.
AB - The recognition that fat contains stem cells has driven further examination into the potential uses of fat and adipose-derived stem cells in a wide number of clinical situations. New information about the harvesting, isolation, and subsequent differentiation properties of isolated adipose-derived stem cells has led to new research into novel tissue-engineered constructs and the transformation of adipose-derived stem cells to induced pluripotent stem cells. Clinically, use of fat grafts and adipose-derived stem cells worldwide and in the United States has dramatically increased in parallel to questions concerning the safety and efficacy of adipose-derived stem cell-based treatments. Currently, the U.S. Food and Drug Administration has not approved the use of isolated adipose-derived stem cells for medical indications.
UR - http://www.scopus.com/inward/record.url?scp=78650068662&partnerID=8YFLogxK
U2 - 10.1097/PRS.0b013e3181f44790
DO - 10.1097/PRS.0b013e3181f44790
M3 - Review article
C2 - 21124133
AN - SCOPUS:78650068662
SN - 0032-1052
VL - 126
SP - 1936
EP - 1946
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
IS - 6
ER -