TY - JOUR
T1 - Biobanking—Budgets and the Role of Pathology Biobanks in Precision Medicine
AU - Andry, Chris
AU - Duffy, Elizabeth
AU - Moskaluk, Christopher A.
AU - McCall, Shannon
AU - Roehrl, Michael H.A.
AU - Remick, Daniel
N1 - Funding Information:
The second major extramural grant that the BTRF supports is a competitive award from the Congressionally Directed Medical Research Program of the Department of Defense to host the Lung Cancer Biospecimen Resource Network (LCBRN).20 The LCBRN is a consortium of 3 institutions that recruit lung cancer patients undergoing cancer resections to donate tissue, bronchial lavage fluid, blood, saliva, and urine samples. Biofluids are collected preoperatively and at intervals postoperatively. Patients are followed continually to obtain clinical follow-up data as well as serial biofluid samples. The UVA serves as the coordinating center of the LCBRN and provides collection kits to all collection sites, so all samples are collected under uniform SOPs and are uniformly labeled and packaged. All biospecimens are sent to UVA for central histology, QC, and storage. Investigators interact with the coordinating center at UVA to submit applications to receive bios-pecimens and annotated clinical data.
Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by NIH grants AA022122 (DGR), AI112887 (DGR), NCI contracts BPV HHSN261200800001E (CDA), and CPTAC HHSN261201600011I (CDA).
Publisher Copyright:
© The Author(s) 2017.
PY - 2017
Y1 - 2017
N2 - Biobanks have become an important component of the routine practice of pathology. At the 2016 meeting of the Association of Pathology Chairs, a series of presentations covered several important aspects of biobanking. An often overlooked aspect of biobanking is the fiscal considerations. A biobank budget must address the costs of consenting, procuring, processing, and preserving high-quality biospecimens. Multiple revenue streams will frequently be necessary to create a sustainable biobank; partnering with other key stakeholders has been shown to be successful at academic institutions which may serve as a model. Biobanking needs to be a deeply science-driven and innovating process so that specimens help transform patient-centered clinical and basic research (ie, fulfill the promise of precision medicine). Pathology’s role must be at the center of the biobanking process. This ensures that optimal research samples are collected while guaranteeing that clinical diagnostics are never impaired. Biobanks will continue to grow as important components in the mission of pathology, especially in the era of precision medicine.
AB - Biobanks have become an important component of the routine practice of pathology. At the 2016 meeting of the Association of Pathology Chairs, a series of presentations covered several important aspects of biobanking. An often overlooked aspect of biobanking is the fiscal considerations. A biobank budget must address the costs of consenting, procuring, processing, and preserving high-quality biospecimens. Multiple revenue streams will frequently be necessary to create a sustainable biobank; partnering with other key stakeholders has been shown to be successful at academic institutions which may serve as a model. Biobanking needs to be a deeply science-driven and innovating process so that specimens help transform patient-centered clinical and basic research (ie, fulfill the promise of precision medicine). Pathology’s role must be at the center of the biobanking process. This ensures that optimal research samples are collected while guaranteeing that clinical diagnostics are never impaired. Biobanks will continue to grow as important components in the mission of pathology, especially in the era of precision medicine.
KW - The Cancer Genome Atlas
KW - biorepository
KW - informed consent
KW - precision medicine
KW - the Cancer Human Biobank
UR - http://www.scopus.com/inward/record.url?scp=85042113507&partnerID=8YFLogxK
U2 - 10.1177/2374289517702924
DO - 10.1177/2374289517702924
M3 - Article
AN - SCOPUS:85042113507
SN - 2374-2895
VL - 4
JO - Academic Pathology
JF - Academic Pathology
ER -