Biology and Metabolism of Sepsis: Innate Immunity, Bioenergetics, and Autophagy

Anthony J. Lewis, Timothy R. Billiar, Matthew R. Rosengart*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Sepsis is a complex, heterogeneous physiologic condition that represents a significant public health concern. While many insights into the pathophysiology of sepsis have been elucidated over the past decades of research, important questions remain. This article serves as a review of several important areas in sepsis research. Understanding the innate immune response has been at the forefront as of late, especially in the context of cytokine-directed therapeutic trials. Cellular bioenergetic changes provide insight into the development of organ dysfunction in sepsis. Autophagy and mitophagy perform crucial cell housekeeping and stress response functions. Finally, age-related changes and their potential impact on the septic response are reviewed.

Original languageEnglish
Pages (from-to)286-293
Number of pages8
JournalSurgical Infections
Issue number3
StatePublished - Jun 2016
Externally publishedYes


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