Biology and principles of scar management and burn reconstruction

Edward E. Tredget*, Benjamin Levi, Matthias B. Donelan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


Hypertrophic scarring is extremely common and is the source of most morbidity related to burns. The biology of hypertrophic healing is complex and poorly understood. Multiple host and injury factors contribute, but protracted healing of partial thickness injury is a common theme. Hypertrophic scarring and heterotopic ossification may share some basic causes involving marrow-derived cells. Several traditional clinical interventions exist to modify hypertrophic scar. All have limited efficacy. Laser interventions for scar modification show promise, but as yet do not provide a definitive solution. Their efficacy is only seen when used as part of a multimodality scar management program.

Original languageEnglish
Pages (from-to)793-815
Number of pages23
JournalSurgical Clinics of North America
Issue number4
StatePublished - Aug 2014
Externally publishedYes


  • Burn reconstruction
  • Fibrocytes
  • Heterotopic ossification
  • Laser
  • Scar


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