Biomarkers: Mining the biofluid proteome

Timothy D. Veenstra*, Thomas P. Conrads, Brian L. Hood, Anthony M. Avellino, Richard G. Ellenbogen, Richard S. Morrison

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

221 Scopus citations

Abstract

Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.

Original languageEnglish
Pages (from-to)409-418
Number of pages10
JournalMolecular and Cellular Proteomics
Volume4
Issue number4
DOIs
StatePublished - Apr 2005
Externally publishedYes

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