TY - JOUR
T1 - Biomarkers
T2 - Mining the biofluid proteome
AU - Veenstra, Timothy D.
AU - Conrads, Thomas P.
AU - Hood, Brian L.
AU - Avellino, Anthony M.
AU - Ellenbogen, Richard G.
AU - Morrison, Richard S.
PY - 2005/4
Y1 - 2005/4
N2 - Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.
AB - Proteomics has brought with it the hope of identifying novel biomarkers for diseases such as cancer. This hope is built on the ability of proteomic technologies, such as mass spectrometry (MS), to identify hundreds of proteins in complex biofluids such as plasma and serum. There are many factors that make this research very challenging beginning with the lack of standardization of sample collection and continuing through the entire analytical process. Fortunately the advances made in the characterization of biofluids using proteomic techniques have been rapid and suggest that these mainly discovery driven approaches will lead to the development of highly specific platforms for diagnosing diseases and monitoring responses to different treatments in the near future.
UR - http://www.scopus.com/inward/record.url?scp=17844371703&partnerID=8YFLogxK
U2 - 10.1074/mcp.M500006-MCP200
DO - 10.1074/mcp.M500006-MCP200
M3 - Article
C2 - 15684407
AN - SCOPUS:17844371703
SN - 1535-9476
VL - 4
SP - 409
EP - 418
JO - Molecular and Cellular Proteomics
JF - Molecular and Cellular Proteomics
IS - 4
ER -