Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine

Chanthap Lon; Michele Spring; Somethy Sok; Soklyda Chann; Rathvichet Bun; Mali Ittiverakul; Nillawan Buathong; Khengheng Thay; Nareth Kong; Yom You; Worachet Kuntawunginn; Charlotte A. Lanteri; David L. Saunders

doi:10.1186/1475-2875-13-96

Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine

Chanthap Lon^*, Michele Spring, Somethy Sok, Soklyda Chann, Rathvichet Bun, Mali Ittiverakul, Nillawan Buathong, Khengheng Thay, Nareth Kong, Yom You, Worachet Kuntawunginn, Charlotte A. Lanteri, David L. Saunders

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.

Original language	English
Article number	96
Pages (from-to)	1-4
Number of pages	4
Journal	Malaria Journal
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/1475-2875-13-96
State	Published - 14 Mar 2014
Externally published	Yes

Keywords

Blackwater fever
Cambodia
Dihydroartemisinin-piperaquine
Malaria
Plasmodium falciparum

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10.1186/1475-2875-13-96

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title = "Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine",

abstract = "The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.",

keywords = "Blackwater fever, Cambodia, Dihydroartemisinin-piperaquine, Malaria, Plasmodium falciparum",

author = "Chanthap Lon and Michele Spring and Somethy Sok and Soklyda Chann and Rathvichet Bun and Mali Ittiverakul and Nillawan Buathong and Khengheng Thay and Nareth Kong and Yom You and Worachet Kuntawunginn and Lanteri, {Charlotte A.} and Saunders, {David L.}",

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AU - Lon, Chanthap

AU - Spring, Michele

AU - Sok, Somethy

AU - Chann, Soklyda

AU - Bun, Rathvichet

AU - Ittiverakul, Mali

AU - Buathong, Nillawan

AU - Thay, Khengheng

AU - Kong, Nareth

AU - You, Yom

AU - Kuntawunginn, Worachet

AU - Lanteri, Charlotte A.

AU - Saunders, David L.

PY - 2014/3/14

Y1 - 2014/3/14

N2 - The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.

AB - The mechanism of massive intravascular haemolysis occurring during the treatment of malaria infection resulting in haemoglobinuria, commonly known as blackwater fever (BWF), remains unknown. BWF is most often seen in those with severe malaria treated with amino-alcohol drugs, including quinine, mefloquine and halofantrine. The potential for drugs containing artemisinins, chloroquine or piperaquine to cause oxidant haemolysis is believed to be much lower, particularly during treatment of uncomplicated malaria. Here is an unusual case of BWF, which developed on day 2 of treatment for uncomplicated Plasmodium falciparum infection with dihydroartemisinin-piperaquine (DHA-PIP) with documented evidence of concomitant seropositivity for Chikungunya infection.

KW - Blackwater fever

KW - Cambodia

KW - Dihydroartemisinin-piperaquine

KW - Malaria

KW - Plasmodium falciparum

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JF - Malaria Journal

IS - 1

M1 - 96

ER -

Blackwater fever in an uncomplicated Plasmodium falciparum patient treated with dihydroartemisinin-piperaquine

Abstract

Keywords

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