Blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress symptoms in military explosives personnel

Marcus K. Taylor; Lisa M. Hernández; Jeremy Stump; Anna E. Tschiffely; Carl W. Goforth; D. Christine Laver; Stephen T. Ahlers

doi:10.1016/j.psychres.2019.112519

Blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress symptoms in military explosives personnel

Marcus K. Taylor, Lisa M. Hernández^*, Jeremy Stump, Anna E. Tschiffely, Carl W. Goforth, D. Christine Laver, Stephen T. Ahlers

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The first of its kind, this study determined whether blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress (PTS) symptoms in 78 military explosives operators. In all models, blast-exposed 5HTTLPR S carriers registered definitively higher PTS symptoms in comparison to non-exposed S carriers, as well as exposed and non-exposed LL carriers (all p < 0.01). All findings were robust to confounding influences of age and traumatic brain injury diagnosis. Not only is blast exposure prevalent in EOD personnel, but it also interacts with genetic predisposition to predict trauma symptoms in this unique, at-risk military population.

Original language	English
Article number	112519
Journal	Psychiatry Research
Volume	280
DOIs	https://doi.org/10.1016/j.psychres.2019.112519
State	Published - Oct 2019
Externally published	Yes

Keywords

Blast exposure
Genetics
Posttraumatic stress

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title = "Blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress symptoms in military explosives personnel",

abstract = "The first of its kind, this study determined whether blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress (PTS) symptoms in 78 military explosives operators. In all models, blast-exposed 5HTTLPR S carriers registered definitively higher PTS symptoms in comparison to non-exposed S carriers, as well as exposed and non-exposed LL carriers (all p < 0.01). All findings were robust to confounding influences of age and traumatic brain injury diagnosis. Not only is blast exposure prevalent in EOD personnel, but it also interacts with genetic predisposition to predict trauma symptoms in this unique, at-risk military population.",

keywords = "Blast exposure, Genetics, Posttraumatic stress",

author = "Taylor, {Marcus K.} and Hern{\'a}ndez, {Lisa M.} and Jeremy Stump and Tschiffely, {Anna E.} and Goforth, {Carl W.} and Laver, {D. Christine} and Ahlers, {Stephen T.}",

note = "Publisher Copyright: {\textcopyright} 2019",

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doi = "10.1016/j.psychres.2019.112519",

language = "English",

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AU - Taylor, Marcus K.

AU - Hernández, Lisa M.

AU - Stump, Jeremy

AU - Tschiffely, Anna E.

AU - Goforth, Carl W.

AU - Laver, D. Christine

AU - Ahlers, Stephen T.

PY - 2019/10

Y1 - 2019/10

N2 - The first of its kind, this study determined whether blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress (PTS) symptoms in 78 military explosives operators. In all models, blast-exposed 5HTTLPR S carriers registered definitively higher PTS symptoms in comparison to non-exposed S carriers, as well as exposed and non-exposed LL carriers (all p < 0.01). All findings were robust to confounding influences of age and traumatic brain injury diagnosis. Not only is blast exposure prevalent in EOD personnel, but it also interacts with genetic predisposition to predict trauma symptoms in this unique, at-risk military population.

AB - The first of its kind, this study determined whether blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress (PTS) symptoms in 78 military explosives operators. In all models, blast-exposed 5HTTLPR S carriers registered definitively higher PTS symptoms in comparison to non-exposed S carriers, as well as exposed and non-exposed LL carriers (all p < 0.01). All findings were robust to confounding influences of age and traumatic brain injury diagnosis. Not only is blast exposure prevalent in EOD personnel, but it also interacts with genetic predisposition to predict trauma symptoms in this unique, at-risk military population.

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JO - Psychiatry Research

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ER -

Blast exposure interacts with genetic variant 5HTTLPR to predict posttraumatic stress symptoms in military explosives personnel

Abstract

Keywords

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