TY - JOUR
T1 - Blast-induced mild traumatic brain injury
AU - Elder, Gregory A.
AU - Mitsis, Effie M.
AU - Ahlers, Stephen T.
AU - Cristian, Adrian
N1 - Funding Information:
Work in the author’s labs is supported by grants from the Department of Veterans Affairs ( 1I01RX000179-01 and I01CX000190-01 ). The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, or the United States Government.
PY - 2010/12
Y1 - 2010/12
N2 - Traumatic brain injury (TBI) has been a major cause of mortality and morbidity in the wars in Iraq and Afghanistan. Blast exposure has been the most common cause of TBI, occurring through multiple mechanisms. What is less clear is whether the primary blast wave causes brain damage through mechanisms that are distinct from those common in civilian TBI and whether multiple exposures to low-level blast can lead to long-term sequelae. Complicating TBI in soldiers is the high prevalence of posttraumatic stress disorder. At present, the relationship is unclear. Resolution of these issues will affect both treatment strategies and strategies for the protection of troops in the field.
AB - Traumatic brain injury (TBI) has been a major cause of mortality and morbidity in the wars in Iraq and Afghanistan. Blast exposure has been the most common cause of TBI, occurring through multiple mechanisms. What is less clear is whether the primary blast wave causes brain damage through mechanisms that are distinct from those common in civilian TBI and whether multiple exposures to low-level blast can lead to long-term sequelae. Complicating TBI in soldiers is the high prevalence of posttraumatic stress disorder. At present, the relationship is unclear. Resolution of these issues will affect both treatment strategies and strategies for the protection of troops in the field.
KW - Blast-related brain injury
KW - Improvised explosive device
KW - Posttraumatic stress disorder
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=78549266164&partnerID=8YFLogxK
U2 - 10.1016/j.psc.2010.08.001
DO - 10.1016/j.psc.2010.08.001
M3 - Review article
C2 - 21093677
AN - SCOPUS:78549266164
SN - 0193-953X
VL - 33
SP - 757
EP - 781
JO - Psychiatric Clinics of North America
JF - Psychiatric Clinics of North America
IS - 4
ER -