Blast traumatic brain injury in the rat using a blast overpressure model

Angela M. Yarnell*, Michael C. Shaughness, Erin S. Barry, Stephen T. Ahlers, Richard M. McCarron, Neil E. Grunberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Traumatic brain injury (TBI) is a serious health concern for civilians and military populations, and blast-induced TBI (bTBI) has become an increasing problem for military personnel over the past 10 years. To understandthe biological and psychological effects of blast-induced injuries and to examine potential interventions that may help to prevent, attenuate, and treat effects of bTBI, it is valuable to conduct controlled animal experiments. This unit discusses available paradigms to model traumatic brain injury in animals, with an emphasis on the relevance of these various models to study blastinduced traumatic brain injury (bTBI). This paper describes the detailed methods of a blast overpressure (BOP) paradigm that has been used to conduct experiments with rats to model blast exposure. This particular paradigm models the pressure wave created by explosions, including improvised explosive devices (IEDs).

Original languageEnglish
Article number9.41
JournalCurrent Protocols in Neuroscience
Issue numberSUPPL.62
StatePublished - Jan 2013
Externally publishedYes


  • Blast overpressure
  • Rat
  • Traumatic brain injury


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