Blood Pressure Targets for Patients with Hypertension and Cardiovascular Disease

LOWER BP TARGETS IN PATIENTS WITH HYPERTENSION AND CARDIOVASCULAR DISEASE Outcomes (average of 4 years) Risk with standard BP target (≤ 140 to 160/90 to 100 mm Hg) Risk with lower BP target (≤ 135/85 mm Hg) NNT or NNH (95% CI) Number of participants (number of studies) Quality of evidence Total mortality 68 per 1,000 72 per 1,000 NA* 9,484 (6) Moderate Serious adverse effects 252 per 1,000 255 per 1,000 NA* 9,484 (6) Low Total CV events 127 per 1,000 113 per 1,000 NA* 9,484 (6) Low CV mortality 31 per 1,000 32 per 1,000 NA* 9,484 (6) Moderate Withdrawals because of adverse effects 7 per 1,000 60 per 1,000 19 (4 to 111) 690 (2) Very low BP= blood pressure; CI= confidence interval; CV= cardiovascular; NA= not applicable; NNH= number needed to harm; NNT= number needed to treat.*-No statistical difference in outcomes. Of those patients with hypertension, only 75 …