TY - JOUR
T1 - Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions
AU - Anderson, Ashley B.
AU - McCarthy, Conor F.
AU - Hoyt, Benjamin W.
AU - Forsberg, Jonathan A.
AU - Potter, Benjamin K.
N1 - Publisher Copyright:
Copyright © 2023 the American Academy of Orthopaedic Surgeons.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.
AB - Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=85175177413&partnerID=8YFLogxK
U2 - 10.5435/JAAOS-D-23-00164
DO - 10.5435/JAAOS-D-23-00164
M3 - Review article
AN - SCOPUS:85175177413
SN - 1067-151X
VL - 31
SP - E940-E948
JO - The Journal of the American Academy of Orthopaedic Surgeons
JF - The Journal of the American Academy of Orthopaedic Surgeons
IS - 21
ER -