Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions

Ashley B. Anderson; Conor F. McCarthy; Benjamin W. Hoyt; Jonathan A. Forsberg; Benjamin K. Potter

doi:10.5435/JAAOS-D-23-00164

Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions

Ashley B. Anderson, Conor F. McCarthy, Benjamin W. Hoyt, Jonathan A. Forsberg, Benjamin K. Potter

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.

Original language	English
Pages (from-to)	E940-E948
Journal	The Journal of the American Academy of Orthopaedic Surgeons
Volume	31
Issue number	21
DOIs	https://doi.org/10.5435/JAAOS-D-23-00164
State	Published - 1 Nov 2023
Externally published	Yes

Access to Document

10.5435/JAAOS-D-23-00164

Cite this

@article{e9964b876810482398416a4e7ab4617a,

title = "Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions",

abstract = "Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.",

author = "Anderson, {Ashley B.} and McCarthy, {Conor F.} and Hoyt, {Benjamin W.} and Forsberg, {Jonathan A.} and Potter, {Benjamin K.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 the American Academy of Orthopaedic Surgeons.",

year = "2023",

month = nov,

day = "1",

doi = "10.5435/JAAOS-D-23-00164",

language = "English",

volume = "31",

pages = "E940--E948",

journal = "The Journal of the American Academy of Orthopaedic Surgeons",

issn = "1067-151X",

publisher = "Lippincott Williams and Wilkins",

number = "21",

}

TY - JOUR

T1 - Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions

AU - Anderson, Ashley B.

AU - McCarthy, Conor F.

AU - Hoyt, Benjamin W.

AU - Forsberg, Jonathan A.

AU - Potter, Benjamin K.

PY - 2023/11/1

Y1 - 2023/11/1

N2 - Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.

AB - Some of the most common human systemic diseases - both benign and malignant - affect bone regulation, formation, and homeostasis (the cellular balance regulated by osteocytes, osteoblasts, and osteoclasts). This review discusses our current understanding of the molecular components and mechanisms that are responsible for homeostasis and interactions resulting in dysregulation (dysfunction due to the loss of the dynamic equilibrium of bone homeostasis). Knowledge of key pathways in bone biology can improve surgeon understanding, clinical recognition, and treatment of bone homeostasis-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=85175177413&partnerID=8YFLogxK

U2 - 10.5435/JAAOS-D-23-00164

DO - 10.5435/JAAOS-D-23-00164

M3 - Review article

C2 - 37467418

AN - SCOPUS:85175177413

SN - 1067-151X

VL - 31

SP - E940-E948

JO - The Journal of the American Academy of Orthopaedic Surgeons

JF - The Journal of the American Academy of Orthopaedic Surgeons

IS - 21

ER -

Bone Homeostasis and Physiology in Normal and Orthopaedic Disease Conditions

Abstract

Access to Document

Fingerprint

Cite this