TY - JOUR
T1 - Bone marrow abnormalities and early bone lesions in multiple myeloma and its precursor disease
T2 - A prospective study using functional and morphologic imaging
AU - Bhutani, Manisha
AU - Turkbey, Baris
AU - Tan, Esther
AU - Korde, Neha
AU - Kwok, Mary
AU - Manasanch, Elisabet E.
AU - Tageja, Nishant
AU - Mailankody, Sham
AU - Roschewski, Mark
AU - Mulquin, Marcia
AU - Carpenter, Ashley
AU - Lamping, Elizabeth
AU - Minter, Alex R.
AU - Weiss, Brendan M.
AU - Mena, Esther
AU - Lindenberg, Liza
AU - Calvo, Katherine R.
AU - Maric, Irina
AU - Usmani, Saad Z.
AU - Choyke, Peter L.
AU - Kurdziel, Karen
AU - Landgren, Ola
N1 - Publisher Copyright:
© 2016 Informa UK Limited.
PY - 2016/5/3
Y1 - 2016/5/3
N2 - The incidence and importance of bone marrow involvement and/or early bone lesions in multiple myeloma (MM) precursor diseases is largely unknown. This study prospectively compared the sensitivity of several imaging modalities in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM. Thirty patients (10 each with MGUS, SMM and MM) were evaluated with skeletal survey, [18F]FDG-PET/CT, [18F]NaF-PET/CT and morphologic dynamic contrast enhanced (DCE)-MRI. An additional 16 SMM patients had skeletal surveys and FDG-PET/CT. Among MGUS patients, DCE-MRI found only one focal marrow abnormality; other evaluations were negative. Among 26 SMM patients, five (19%) were re-classified as MM based on lytic bone lesions on CT and six had unifocal or diffuse marrow abnormality. Among MM, marrow abnormalities were observed on FDG-PET/CT in 8/10 patients and on DCE-MRI in nine evaluable patients. Abnormal NaF uptake was observed only in MM patients with lytic lesions on CT, providing no additional clinical information.
AB - The incidence and importance of bone marrow involvement and/or early bone lesions in multiple myeloma (MM) precursor diseases is largely unknown. This study prospectively compared the sensitivity of several imaging modalities in monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM) and MM. Thirty patients (10 each with MGUS, SMM and MM) were evaluated with skeletal survey, [18F]FDG-PET/CT, [18F]NaF-PET/CT and morphologic dynamic contrast enhanced (DCE)-MRI. An additional 16 SMM patients had skeletal surveys and FDG-PET/CT. Among MGUS patients, DCE-MRI found only one focal marrow abnormality; other evaluations were negative. Among 26 SMM patients, five (19%) were re-classified as MM based on lytic bone lesions on CT and six had unifocal or diffuse marrow abnormality. Among MM, marrow abnormalities were observed on FDG-PET/CT in 8/10 patients and on DCE-MRI in nine evaluable patients. Abnormal NaF uptake was observed only in MM patients with lytic lesions on CT, providing no additional clinical information.
KW - MGUS
UR - http://www.scopus.com/inward/record.url?scp=84964048543&partnerID=8YFLogxK
U2 - 10.3109/10428194.2015.1090572
DO - 10.3109/10428194.2015.1090572
M3 - Article
C2 - 26690712
AN - SCOPUS:84964048543
SN - 1042-8194
VL - 57
SP - 1114
EP - 1121
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 5
ER -