Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's Syndrome

H. Umesha Shetty; Harold W. Holloway; Larisa D. Acevedo; Zygmunt Galdzicki

doi:10.1042/bj3130031

Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's Syndrome

H. Umesha Shetty^*
, Harold W. Holloway
, Larisa D. Acevedo
, Zygmunt Galdzicki

^*Corresponding author for this work

Anatomy, Physiology, and Genetics

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.

Original language	English
Pages (from-to)	31-33
Number of pages	3
Journal	Biochemical Journal
Volume	313
Issue number	1
DOIs	https://doi.org/10.1042/bj3130031
State	Published - 1 Jan 1996

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title = "Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's Syndrome",

abstract = "myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.",

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AU - Holloway, Harold W.

AU - Acevedo, Larisa D.

AU - Galdzicki, Zygmunt

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AB - myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects.

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Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's Syndrome

Abstract

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