Brain cancer incidence: A comparison of active-duty military and general populations

Julie A. Bytnar, Jie Lin, Yvonne L. Eaglehouse, Lindsey Enewold, Craig D. Shriver, Kangmin Zhu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background In the USA, brain cancer disproportionately affects young adults. The US military has a younger age structure than the general population and may have differential exposures related to brain cancer. This study aimed to compare the incidence rates of brain cancer in the active-duty military and general populations to provide clues for future etiologic research. The rates between military service branches were also compared. Methods The data for this study were from the Department of Defense's Automated Central Tumor Registry (ACTUR) and the National Cancer Institute's Surveillance, Epidemiology, and End Results 9 (SEER-9) registries. Age- and sex-adjusted incidence rates of malignant neuroepithelial brain cancer among adults 20-54 years of age from 1990-2013 were calculated and compared between the two populations, given as incidence rate ratios (IRRs) with 95% confidence intervals (CIs). Results The age and sex-adjusted incidence rate for malignant neuroepithelial brain cancer was significantly lower in the active-duty population than in the US general population (IRR = 0.62, 95% CI, 0.56-0.68). The reduced incidence rate in the active-duty population was observed in men, all races, individuals 20-44 of age, and for all histological subtypes and time periods assessed. There were no significant differences in rates between the military service branches. Conclusion The incidence rates of neuroepithelial brain cancer were lower in the active-duty military population than the US general population. This study highlights the need for more research to enhance our understanding of variations in brain cancer incidence between these two populations.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalEuropean Journal of Cancer Prevention
Issue number4
StatePublished - 1 Jul 2021
Externally publishedYes


  • SEER Program
  • carcinoma
  • incidence
  • military personnel
  • neuroepithelial brain cancer


Dive into the research topics of 'Brain cancer incidence: A comparison of active-duty military and general populations'. Together they form a unique fingerprint.

Cite this