TY - JOUR
T1 - Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells
AU - Joyner, P. Matthew
AU - Waters, Amanda L.
AU - Williams, Russell B.
AU - Powell, Douglas R.
AU - Janakiram, Naveena B.
AU - Rao, Chinthalapally V.
AU - Cichewicz, Robert H.
PY - 2011/4/25
Y1 - 2011/4/25
N2 - Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.
AB - Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.
UR - http://www.scopus.com/inward/record.url?scp=79955428971&partnerID=8YFLogxK
U2 - 10.1021/np100775a
DO - 10.1021/np100775a
M3 - Article
C2 - 21438584
AN - SCOPUS:79955428971
SN - 0163-3864
VL - 74
SP - 857
EP - 861
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 4
ER -