Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

P. Matthew Joyner, Amanda L. Waters, Russell B. Williams, Douglas R. Powell, Naveena B. Janakiram, Chinthalapally V. Rao, Robert H. Cichewicz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

Original languageEnglish
Pages (from-to)857-861
Number of pages5
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
StatePublished - 25 Apr 2011
Externally publishedYes

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