Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

P. Matthew Joyner; Amanda L. Waters; Russell B. Williams; Douglas R. Powell; Naveena B. Janakiram; Chinthalapally V. Rao; Robert H. Cichewicz

doi:10.1021/np100775a

Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

P. Matthew Joyner, Amanda L. Waters, Russell B. Williams, Douglas R. Powell, Naveena B. Janakiram, Chinthalapally V. Rao, Robert H. Cichewicz

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

Original language	English
Pages (from-to)	857-861
Number of pages	5
Journal	Journal of Natural Products
Volume	74
Issue number	4
DOIs	https://doi.org/10.1021/np100775a
State	Published - 25 Apr 2011
Externally published	Yes

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title = "Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells",

abstract = "Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.",

author = "Joyner, {P. Matthew} and Waters, {Amanda L.} and Williams, {Russell B.} and Powell, {Douglas R.} and Janakiram, {Naveena B.} and Rao, {Chinthalapally V.} and Cichewicz, {Robert H.}",

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AU - Joyner, P. Matthew

AU - Waters, Amanda L.

AU - Williams, Russell B.

AU - Powell, Douglas R.

AU - Janakiram, Naveena B.

AU - Rao, Chinthalapally V.

AU - Cichewicz, Robert H.

PY - 2011/4/25

Y1 - 2011/4/25

N2 - Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

AB - Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

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JO - Journal of Natural Products

JF - Journal of Natural Products

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ER -

Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

Abstract

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