@article{dfd9d12b246b44eca3c54f8927fe6ba1,
title = "Bronchial epithelial gene expression and interstitial lung abnormalities",
abstract = "Introduction: Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality and rapid decline in lung function. Understanding the differential gene expression that occurs in the lungs of participants with fibrotic ILA may provide insight into development of a useful biomarker for early detection and therapeutic targets for progressive pulmonary fibrosis. Methods: Measures of ILA and gene expression data were available in 213 participants in the Detection of Early Lung Cancer Among Military Personnel (DECAMP1 and DECAMP2) cohorts. ILA was defined using Fleischner Society guidelines and determined by sequential reading of computed tomography (CT) scans. Primary analysis focused on comparing gene expression in ILA with usual interstitial pneumonia (UIP) pattern with those with no ILA. Results: ILA was present in 51 (24%) participants, of which 16 (7%) were subtyped as ILA with a UIP pattern. One gene, pro platelet basic protein (PPBP) and seventeen pathways (e.g. TNF-α signalling) were significantly differentially expressed between those with a probable or definite UIP pattern of ILA compared to those without ILA. 16 of these 17 pathways, but no individual gene, met significance when comparing those with ILA to those without ILA. Conclusion: Our study demonstrates that abnormal inflammatory processes are apparent in the bronchial airway gene expression profiles of smokers with and without lung cancer with ILA. Future studies with larger and more diverse populations will be needed to confirm these findings.",
keywords = "Gene expression, ILA, Interstitial lung abnormalities, Interstitial lung disease, Lung fibrosis",
author = "Menon, {Aravind A.} and Minyi Lee and Xu Ke and Putman, {Rachel K.} and Takuya Hino and Rose, {Jonathan A.} and Fenghai Duan and Ash, {Samuel Y.} and Cho, {Michael H.} and O{\textquoteright}Connor, {George T.} and Jos{\'e}e Dupuis and Hiroto Hatabu and Lenburg, {Marc E.} and Billatos, {Ehab S.} and Hunninghake, {Gary M.} and Avi Spira and Elizabeth Moses and Jennifer Beane and Josh Campbell and Jack Cunningham and Gang Liu and Hanqiao Liu and Sherry Zhang and Jiarui Zhang and Xingyi Shi and Carter Merenstein and Yue Zhao and Denise Aberle and Mitchell Schnall and Charles Apgar and Irene Mahon and Lindsey Dymond and Joe Bauza and Sarah Gevo and Constantine Gastonis and Helga Marquez and David Elashoff and Ignacio Wistuba and Humam Kadara and Junya Fujimoto and Clifton Dalgard and Matthew Wilkerson and Denise Aberle and George Washko and Kinsey, {Charles M.} and Denise Fine and Ron Goldstein and Kathleen LaCerda and John Battaile and Mitchell Kroll and Bob Keith and Mary Jackson and Steve Dubinett and Gina Lee and Babak Aryanfar and Rafael Corona and Anil Vachani and Sam Soloman and Charles Atwood and Gregory Owens and Hanna Edvardsson and Pierre Massion and Trey Helton and Mary Reid and Chris Kuzniewski and Jacob Carmichael and Holly LaPerriere and J. ScottParrish and Lindsey White and Anna Kaur and Robert Browning and Maggie Nelissery and Folashade Akanni and Luis Rojas",
note = "Funding Information: DECAMP Investigators Executive Center—Boston University: Avi Spira, MD*Ŧ, Elizabeth Moses, PhD*, Jennifer Beane, PhD, Josh Campbell, PhD, Jack Cunningham, Gang Liu, PhD, Hanqiao Liu, Sherry Zhang, Jiarui Zhang, Xu Ke, Xingyi Shi, Carter Merenstein, MS, Yue Zhao (Boston University School of Medicine); Ehab Billatos, MD*Ŧ(Pulmonary Center, Boston University School of Medicine, Boston); Marc Lenburg, PhDŦ(Section of Computational Biomedicine, Boston University School of Medicine). Coordinating Center—American College of Radiology: Denise Aberle, MD*, Mitchell Schnall, MD, PhD*, Charles Apgar, MBA*, Irene Mahon, RN, MPH*, Lindsey Dymond, Joe Bauza, Sarah Gevo (American College of Radiology). Data Coordinating Center—Brown University: Constantine Gastonis, PhD*, Helga Marquez, David Elashoff, PhDŦ(Brown University); Fenghai Duan, PhD*Ŧ(Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI). Pathology Core—MD Anderson Cancer Center: Ignacio Wistuba, MD, Humam Kadara, PhD, Junya Fujimoto, MD, PhD (MD Anderson Cancer Center). Sequencing Core—Uniformed Services University of the Health Science: Clifton Dalgard, PhD, Matthew Wilkerson, PhD (Uniformed Services University of the Health Science). Imaging Core: Denise Aberle, MD (American College of Radiology); George Washko, MD* (Division of Pulmonary and Critical Care Medicine, Brigham and Women{\textquoteright}s Hospital, Boston, MA); Charles M Kinsey, MD, MPH (University of Vermont, Medical Center); Fenghai Duan, PhD (Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health). Clinical Centers: Denise Fine (Boston University); Ron Goldstein, MD, Kathleen LaCerda (Boston VA); John Battaile, MD, Mitchell Kroll, (Dallas VA); Bob Keith, MD, Mary Jackson, (Denver VA); Steve Dubinett, MD, Gina Lee, MD, Babak Aryanfar, Rafael Corona (UCLA); Anil Vachani, MDŦ, Sam Soloman (University of Pennsylvania); Charles Atwood, MD, Gregory Owens, Hanna Edvardsson (Pittsburgh VA); Pierre Massion, MD (Vanderbilt University); Trey Helton (Nashville VA); Mary Reid (Roswell Park Cancer Institute); Chris Kuzniewski, MD, Jacob Carmichael, MD, Holly LaPerriere (Naval Medical Center Portsmouth); J. Scott Parrish, MD, Lindsey White, Anna Kaur (Naval Medical Center San Diego); Robert Browning Jr., MD*Ŧ, Maggie Nelissery, Folashade Akanni, Luis Rojas (Walter Reed Army Medical Center). *Denotes DECAMP Executive Committee Member.ŦDenotes DECAMP Data Access Committee Member. Funding Information: Dr. Putman is supported by National Institutes of Health (NIH) Grant K08 HL140087. Dr. Rose is supported by NIH Grant T32 HL 76331. Dr. Cho is supported by NIH Grants R01 HL153248, R01 HL135142, R01 HL149861, R01 HL137927, and R01 HL137148. Dr. O{\textquoteright}Connor is supported by NIH Grant OT2 OD026553. Dr. Hatabu is supported by NIH grants R01 CA203636, U01 CA209414, R01 HL111024, R01 HL135142, and R01 HL130974. Dr. Lenburg is supported by NIH grants R01 CA210360, U01 CA214182, U01 CA196408, U2C CA233238. Dr. Hunninghake and this work was supported by NIH Grants R01 HL111024, R01 HL130974, and R01 135142. DECAMP study is supported by funds from the Department of Defense (W81XWH-11-2-0161), the National Cancer Institute (U01CA196408), and Johnson and Johnson Services, Inc (JJSI). Publisher Copyright: {\textcopyright} 2023, BioMed Central Ltd., part of Springer Nature.",
year = "2023",
month = dec,
doi = "10.1186/s12931-023-02536-w",
language = "English",
volume = "24",
journal = "Respiratory Research",
issn = "1465-9921",
number = "1",
}