Burn Shock and Resuscitation: Review and State of the Science

Robert Cartotto*, David M. Burmeister, John C. Kubasiak

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Burn shock and acute fluid resuscitation continue to spark intense interest and debate among burn clinicians. Following a major burn injury, fluid resuscitation of burn shock is life-saving, but paradoxically can also be a source of increased morbidity and mortality because of the unintended consequence of systemic edema formation. Considerable research over the past two decades has been devoted to understanding the mechanisms of edema formation, and to develop strategies to curb resuscitation fluids and limit edema development. Recognition of burn endotheliopathy - injury to the endothelium's glycocalyx layer - is one of the most important recent developments in our understanding of burn shock pathophysiology. Newer monitoring approaches and resuscitation endpoints, along with alternative resuscitation strategies to crystalloids alone, such as administration of albumin, or plasma, or high-dose ascorbic acid, have had mixed results in limiting fluid creep. Clear demonstration of improvements in outcomes with all of these approaches remains elusive. This comprehensive review article on burn shock and acute resuscitation accompanies the American Burn Association's State of the Science meeting held in New Orleans, LA on November 2 to 3, 2021 and the Proceedings of that conference published in this journal.

Original languageEnglish
Pages (from-to)567-585
Number of pages19
JournalJournal of Burn Care and Research
Issue number3
StatePublished - 1 May 2022
Externally publishedYes


Dive into the research topics of 'Burn Shock and Resuscitation: Review and State of the Science'. Together they form a unique fingerprint.

Cite this