TY - JOUR
T1 - Calcitonin gene-related peptide
T2 - a potent modulator of coronary flow
AU - Ezra, David
AU - Laurindo, Francisco R.M.
AU - Goldstein, David S.
AU - Goldstein, Robert E.
AU - Feuerstein, Giora
N1 - Funding Information:
This work was supported by the Uniformed Services University of the Health Sciences, Protocols No. RO-9211 and RO-8346. David Ezra is a recipient of an International Fellowship in Clinical Pharmacologyf rom the Merck Foundation; his present address is: Dept. of Medicine and Clinical Pharmacology Unit, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer, Israel. The authors wish to thank Ms. Leslie S. Watts for her help in the preparation of this manuscript.
PY - 1987/5/7
Y1 - 1987/5/7
N2 - Calcitonin gene-related peptide (CGRP) has been identified in nerve fibers innervating cardiovascular elements and particularly in coronary arteries (CA). To investigate its potential role in modulating coronary blood flow, we injected rat-CGRP into the CA of pentobarbital anesthetized, open chest pigs. Significant dose-related increments in coronary flow were observed. The rise in coronary flow was characterized by unusually, slow onset, late peak and prolonged duration. Arterial pressure, heart rate (HR) and myocardial contractility were unchanged, except at the highest dose (3.0 nmol), which produced mild systemic hypotension and sinus tachycardia. Coronary levels of catecholamines and 6-keto-PGF1α were uncharged by CGRP. The direct, sustained, and potent dilatory activity of CGRP, in coronary arteries of the pig together with anatomical CGRP localization in this site suggest a role for this neuropeptide in hemodynamic regulation.
AB - Calcitonin gene-related peptide (CGRP) has been identified in nerve fibers innervating cardiovascular elements and particularly in coronary arteries (CA). To investigate its potential role in modulating coronary blood flow, we injected rat-CGRP into the CA of pentobarbital anesthetized, open chest pigs. Significant dose-related increments in coronary flow were observed. The rise in coronary flow was characterized by unusually, slow onset, late peak and prolonged duration. Arterial pressure, heart rate (HR) and myocardial contractility were unchanged, except at the highest dose (3.0 nmol), which produced mild systemic hypotension and sinus tachycardia. Coronary levels of catecholamines and 6-keto-PGF1α were uncharged by CGRP. The direct, sustained, and potent dilatory activity of CGRP, in coronary arteries of the pig together with anatomical CGRP localization in this site suggest a role for this neuropeptide in hemodynamic regulation.
KW - (Neuropeptides)
KW - Blood pressure
KW - Calcitonin gene-related peptide
KW - Cardiac functions
KW - Coronary blood flow
KW - Heart rate
UR - http://www.scopus.com/inward/record.url?scp=0023220113&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(87)90187-7
DO - 10.1016/0014-2999(87)90187-7
M3 - Article
C2 - 2440702
AN - SCOPUS:0023220113
SN - 0014-2999
VL - 137
SP - 101
EP - 105
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 1
ER -